HAVCR1 Human

Hepatitis A Virus Cellular Receptor 1 Human Recombinant
Cat. No.
BT9011
Source
Escherichia Coli.
Synonyms
Hepatitis A Virus Cellular Receptor 1, T-Cell Immunoglobulin Mucin Family Member 1, T-Cell Immunoglobulin Mucin Receptor 1, T-Cell Membrane Protein 1, Kidney Injury Molecule 1, HAVCR-1, TIMD-1, HAVCR, KIM-1, TIM-1, TIMD1, TIM1, KIM1, TIM, T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1, T Cell Immunoglobin Domain And Mucin Domain Protein 1, HAVCR1.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

HAVCR1 Human Recombinant produced in E. coli is a single polypeptide chain containing 298 amino acids (21-295aa) and having a molecular mass of 31.9kDa.
HAVCR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
The hepatitis A virus cellular receptor 1 (HAVCR1) is a membrane receptor for both the human hepatitis A virus (HHAV) and TIMD4. It is a type I transmembrane structural glycoprotein that is located in the renal proximal tubule epithelial cells. This protein may be involved in the control of asthma and allergic diseases. The reference genome represents an allele which retains a MTTVP amino acid segment that presents defense against atopy in HHAV seropositive individuals.
Description
Recombinant human HAVCR1 produced in E. coli is a single polypeptide chain containing 298 amino acids (21-295aa) with a molecular mass of 31.9kDa. It is fused to a 23 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques.
Physical Appearance
Sterile, colorless solution.
Formulation
The HAVCR1 solution (1mg/ml) is formulated with 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep refrigerated at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 85% by SDS-PAGE.
Synonyms
Hepatitis A Virus Cellular Receptor 1, T-Cell Immunoglobulin Mucin Family Member 1, T-Cell Immunoglobulin Mucin Receptor 1, T-Cell Membrane Protein 1, Kidney Injury Molecule 1, HAVCR-1, TIMD-1, HAVCR, KIM-1, TIM-1, TIMD1, TIM1, KIM1, TIM, T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1, T Cell Immunoglobin Domain And Mucin Domain Protein 1, HAVCR1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSSVKVGGE AGPSVTLPCH YSGAVTSMCW NRGSCSLFTC QNGIVWTNGT HVTYRKDTRY KLLGDLSRRD VSLTIENTAV SDSGVYCCRV EHRGWFNDMK ITVSLEIVPP KVTTTPIVTT VPTVTTVRTS TTVPTTTTVP MTTVPTTTVP TTMSIPTTTT VLTTMTVSTT TSVPTTTSIP TTTSVPVTTT VSTFVPPMPL PRQNHEPVAT SPSSPQPAET HPTTLQGAIR REPTSSPLYS YTTDGNDTVT ESSDGLWNNN QTQLFLEHSL LTANTTKG

Product Science Overview

Structure and Function

HAVCR1 is a type I transmembrane glycoprotein that includes:

  • An N-terminal immunoglobulin (Ig)-like domain
  • A mucin domain with distinct length
  • A single transmembrane domain
  • A short cytoplasmic tail

The protein is involved in various biological processes, including viral entry into host cells, immune response regulation, and modulation of allergic responses and asthma . It is also known as Kidney Injury Molecule-1 (KIM-1) due to its significant upregulation in injured kidneys .

Role in Hepatitis A Virus Infection

HAVCR1 serves as a cellular receptor for HAV, facilitating the virus’s entry into host cells . The interaction between HAV and HAVCR1 involves specific physiological requirements, such as temperature, calcium, and pH levels . Soluble forms of HAVCR1 can bind to and neutralize HAV particles, mimicking the cell entry process of the virus .

Recombinant HAVCR1

Recombinant forms of HAVCR1 are produced using various expression systems, such as HEK293 cells, to study its interaction with HAV and its role in viral pathogenesis . These recombinant proteins are valuable tools for research, enabling scientists to investigate the molecular mechanisms underlying HAV infection and to develop potential therapeutic interventions.

Clinical Significance

Beyond its role in HAV infection, HAVCR1 is implicated in several other conditions:

  • Asthma and Allergic Diseases: HAVCR1 is involved in the regulation of immune responses, particularly in allergic reactions and asthma .
  • Kidney Injury: As KIM-1, HAVCR1 is highly upregulated in response to kidney injury, making it a potential biomarker for renal damage .
  • Transplant Tolerance: HAVCR1 plays a role in transplant tolerance, influencing the immune response to transplanted tissues .

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