H1N1 Antibody
Protein atonal homolog 1, ATH1, bHLHa14, HATH1, MATH-1.
Description
Product Specs
H1N1 is a subtype of the Influenza A virus. It has evolved into many strains, including those responsible for the Spanish Flu, mild human flu, endemic pig strains, and various strains found in birds. The virus is a roughly spherical particle, about 100nm in diameter, enclosed in a lipid bilayer derived from its host's plasma membrane. Embedded in this membrane are two integral membrane antigens: approximately 500 copies of hemagglutinin ("H") and about 100 copies of neuraminidase ("N").
The antibody is supplied at a concentration of 1mg/ml in a solution of PBS at pH 7.4, with 10% glycerol and 0.02% sodium azide.
This H1N1 antibody has been validated for use in ELISA and Western blot analysis to ensure its specificity and reactivity. However, optimal working dilutions should be determined empirically for each application to achieve the best results.
Protein atonal homolog 1, ATH1, bHLHa14, HATH1, MATH-1.
H1N1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
PAT1G7AT.
Recombinant human H1N1/HA1 (18-344aa) purified from Baculovirus.
Mouse IgG1 heavy chain and κ light chain.
Product Science Overview
Influenza A virus is a significant pathogen responsible for seasonal flu epidemics and occasional pandemics. One of the critical components of the Influenza A virus is the hemagglutinin (HA) protein, which plays a crucial role in the virus’s ability to infect host cells. The H1N1 subtype of Influenza A has been particularly notable for its impact on public health. This article delves into the background of the “Influenza-A Hemagglutinin H1N1, Mouse Anti Human” antibody, its significance, and its applications in scientific research.
Hemagglutinin is a glycoprotein found on the surface of the Influenza A virus. It is responsible for binding the virus to the host cell’s surface receptors, facilitating viral entry into the cell. The HA protein is also a primary target for the host immune response, making it a critical focus for vaccine development and therapeutic interventions.
The H1N1 subtype of Influenza A virus is characterized by its specific HA protein, which has undergone various mutations over time, leading to different strains. The 2009 H1N1 pandemic, also known as “swine flu,” highlighted the importance of understanding and targeting the HA protein to control the spread of the virus.
Mouse anti-human antibodies are antibodies produced in mice that are specific to human antigens. These antibodies are widely used in research and diagnostic applications due to their high specificity and affinity for their target antigens. In the context of Influenza A H1N1, mouse anti-human antibodies targeting the HA protein are valuable tools for studying the virus’s behavior, developing diagnostic assays, and evaluating potential vaccines and therapeutics.
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Diagnostic Assays: These antibodies are used in various diagnostic assays, such as ELISA (Enzyme-Linked Immunosorbent Assay), to detect the presence of Influenza A H1N1 virus in clinical samples. Their high specificity ensures accurate detection, which is crucial for timely diagnosis and treatment.
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Vaccine Development: The HA protein is a primary target for vaccine development. Mouse anti-human antibodies against H1N1 HA can be used to evaluate the efficacy of candidate vaccines by measuring the immune response they elicit. This helps in the selection of the most promising vaccine candidates for further development.
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Therapeutic Research: These antibodies are also used in therapeutic research to develop antiviral drugs that target the HA protein. By understanding how these antibodies interact with the HA protein, researchers can design drugs that inhibit the virus’s ability to infect host cells.
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Basic Research: In addition to applied research, these antibodies are valuable tools for basic research into the biology of the Influenza A virus. They can be used to study the structure and function of the HA protein, as well as the mechanisms by which the virus evades the host immune response.
