G CSF Human, HEK
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Description
The G-CSF is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Granulocyte-Colony Stimulating Factor (G-CSF) is a glycoprotein that plays a crucial role in hematopoiesis, the process of forming blood cellular components. It specifically stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream . The human recombinant form of G-CSF, expressed in Human Embryonic Kidney (HEK) cells, is a significant advancement in biotechnology and medicine.
Human recombinant G-CSF is produced using HEK 293 cells, a specific cell line derived from human embryonic kidney cells. These cells are widely used in biotechnology for their ability to produce high yields of recombinant proteins. The recombinant G-CSF expressed in HEK cells is biologically active and structurally similar to the naturally occurring protein .
G-CSF is a proliferation, differentiation, survival, and activation factor for hematopoietic cells of the neutrophilic granulocyte lineage . It is produced by various cells, including macrophages, monocytes, fibroblasts, and endothelial cells, in response to specific stimuli such as endotoxins and cytokines . The primary function of G-CSF is to stimulate the bone marrow to produce and release neutrophils, a type of white blood cell essential for fighting infections .
G-CSF binds to its specific receptor on the surface of target cells, primarily neutrophils and their precursors . This binding activates intracellular signaling pathways that promote the proliferation, differentiation, and survival of these cells. Additionally, G-CSF enhances the functional activity of mature neutrophils, including their ability to combat infections .
Recombinant human G-CSF is used clinically to treat neutropenia, a condition characterized by low levels of neutrophils . It is commonly administered to patients undergoing chemotherapy, which can reduce white blood cell counts and increase the risk of infections . G-CSF helps to restore neutrophil levels, reducing the risk of infections and allowing patients to continue their chemotherapy treatments on schedule . It is also used in stem cell transplantation to mobilize stem cells from the bone marrow into the bloodstream for collection and subsequent transplantation .
