FZD10 Human
HEK293 Cells.
FZ-10, CD350, Fz10, FzE7, frizzled-10, hFz10, FZD10, frizzled class receptor 10.
Sterile Filtered colorless solution.
Greater than 90.0% as determined by SDS-PAGE.
Description
FZD10 Human Recombinant is a single, glycosylated, polypeptide chain (21-225 a.a) containing a total of 444 amino acids and having a molecular mass of 50.0 kDa.
FZD10is fused to a 239 a.a hIgG-His-Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
FZ-10, CD350, Fz10, FzE7, frizzled-10, hFz10, FZD10, frizzled class receptor 10.
HEK293 Cells.
ISSMDMERPG DGKCQPIEIP MCKDIGYNMT RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH VEKSASCAPL CTPGVDVYWS REDKRLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALPAPIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH.
Product Science Overview
FZD10 functions as a receptor for Wnt proteins. It primarily operates within the canonical Wnt/beta-catenin signaling pathway . This pathway involves the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and activation of Wnt target genes . Additionally, there is evidence suggesting that FZD10 may also participate in a second signaling pathway involving protein kinase C (PKC) and calcium fluxes . However, it is not yet clear if this represents a distinct pathway or if it can be integrated into the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase .
The expression of FZD10 is significantly up-regulated in certain types of cancer, including primary colon cancer . This up-regulation suggests that FZD10 may play a role in tumorigenesis and could be a potential target for cancer therapy. Diseases associated with FZD10 include spinal cord astrocytoma and colorectal cancer .
Human recombinant FZD10 is used in research to study its role in the Wnt signaling pathway and its implications in various diseases. By understanding how FZD10 functions and interacts with other proteins, researchers can develop targeted therapies for conditions where this receptor is implicated.
