FLRT3 Human
Description
FLRT3 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The FLRT3 gene encodes a protein that is expressed in many tissues, including distinct areas of the developing brain . The protein structure of FLRT3 resembles small leucine-rich proteoglycans found in the extracellular matrix. It contains fibronectin-like domains that facilitate its role in cell adhesion and receptor signaling .
FLRT3 is involved in several key biological functions:
- Cell-Cell Adhesion: FLRT3 mediates cell-cell contacts that promote an increase in both neurite number and length .
- Axon Guidance: It exerts an attractive or repulsive role in axon guidance, depending on its interaction partners .
- Neurite Outgrowth: FLRT3 promotes neurite outgrowth in vitro .
- Vascular Development: It plays a role in the spatial organization of brain neurons and vascular development in the retina .
Recent research has highlighted the role of FLRT3 in neuropathic pain. Neuropathic pain is a chronic condition that occurs frequently after nerve injury and is associated with abnormal neuronal excitability in the spinal cord . FLRT3 is upregulated in the dorsal horn following peripheral nerve injury and is involved in the modulation of neurite outgrowth, axon pathfinding, and cell adhesion . In rodent models, increased expression of FLRT3 in the dorsal root ganglion (DRG) has been shown to induce mechanical allodynia, a condition characterized by pain from stimuli that do not normally provoke pain .
FLRT3 has been associated with various diseases, including Hypogonadotropic Hypogonadism 21 with or without anosmia and Kallmann Syndrome . Its involvement in nervous system development and signaling pathways, such as those mediated by FGFR2, underscores its importance in both normal physiology and disease states .
Recombinant human FLRT3 is used in research to study its functions and interactions. It is produced using recombinant DNA technology, which allows for the expression of the human FLRT3 protein in various host systems. This recombinant protein is valuable for investigating the molecular mechanisms underlying its role in cell adhesion, migration, and axon guidance.
