FLRT3 Human, HEK
HEK293 Cells.
Greater than 95.0% as determined by SDS-PAGE.
Description
FLRT3 Human Recombinant is a single, glycosylated, polypeptide chain (29-528 a.a) containing a total of 506 amino acids and having a molecular mass of 57.3 kDa.
FLRT3 is fused to a 6 a.a his-Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
HEK293 Cells.
KSCPSVCRCD AGFIYCNDRF LTSIPTGIPE DATTLYLQNN QINNAGIPSD LKNLLKVERI YLYHNSLDEF PTNLPKYVKE LHLQENNIRT ITYDSLSKIP YLEELHLDDN SVSAVSIEEG AFRDSNYLRL LFLSRNHLST IPWGLPRTIE ELRLDDNRIS TISSPSLQGL TSLKRLVLDG NLLNNHGLGD KVFFNLVNLT ELSLVRNSLT AAPVNLPGTN LRKLYLQDNH INRVPPNAFS
YLRQLYRLDM SNNNLSNLPQ GIFDDLDNIT QLILRNNPWY CGCKMKWVRD WLQSLPVKVN VRGLMCQAPE KVRGMAIKDL NAELFDCKDS GIVSTIQITT AIPNTVYPAQ GQWPAPVTKQ PDIKNPKLTK DHQTTGSPSR KTITITVKSV TSDTIHISWK LALPMTALRL SWLKLGHSPA FGSITETIVT GERSEYLVTA LEPDSPYKVC MVPMETSNLY LFDETPVCIE TETAPLRMYN
PTTTLNREQE KEPYKNPNLP HHHHHH.
Product Science Overview
The FLRT3 gene encodes a transmembrane cell-adhesion protein. The protein structure includes a cluster of leucine-rich repeats and one fibronectin type III domain within its extracellular region . These structural features are similar to small leucine-rich proteoglycans found in the extracellular matrix .
FLRT3 is expressed in many tissues and plays a crucial role in various biological processes. It functions in cell-cell adhesion, cell migration, and axon guidance . Depending on its interaction partners, FLRT3 can exert either attractive or repulsive roles. For instance, it interacts with ADGRL3 and other latrophilins to mediate cell-cell adhesion . Additionally, FLRT3 is involved in the spatial organization of brain neurons and vascular development in the retina .
FLRT3 has been associated with several diseases, including Hypogonadotropic Hypogonadism 21 and Kallmann Syndrome . It also plays a role in neuropathic pain. Increased expression of FLRT3 in the dorsal root ganglion has been shown to induce neuropathic pain in rats . This suggests that FLRT3 is involved in the regulation of neuronal excitability and pain sensitization following nerve injury .
Research on FLRT3 continues to uncover its diverse roles in cell adhesion, migration, and signaling. The human recombinant form of FLRT3, produced in HEK cells, is used in various studies to understand its function and potential therapeutic applications.
