FAM50A Human
Family with Sequence Similarity 50, Member A Human Recombinant
Cat. No.
BT8187
Source
E.coli.
Synonyms
9F, DXS9928E, HXC-26, HXC26, XAP5, XAP-5.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
FAM50A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (150-339 a.a.) and having a molecular mass of 25.2kDa.
FAM50A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FAM50A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
FAM50A, a member of the FAM50 family, exhibits high conservation in length and sequence across various species. As a basic protein, it contains a nuclear localization signal and possesses potential functionality as a DNA-binding protein or a transcriptional factor. FAM50A is ubiquitously expressed, with notable abundance in fetal brain, liver, and kidney. In adults, elevated levels are observed in skeletal muscle, spleen, thymus, prostate, and the small intestine.
Description
Recombinant FAM50A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 213 amino acids (residues 150-339). With a molecular weight of 25.2 kDa, it features a 23 amino acid His-tag fused at the N-terminus. Purification is achieved using proprietary chromatographic methods.
Physical Appearance
The product is a sterile, colorless solution.
Formulation
The FAM50A protein solution (0.5 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 20% glycerol, and 1 mM DTT.
Stability
For short-term storage (2-4 weeks), the product should be kept at 4°C. For extended storage, freezing at -20°C is recommended. Adding a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Repeated freeze-thaw cycles should be avoided.
Purity
The purity of the product is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
9F, DXS9928E, HXC-26, HXC26, XAP5, XAP-5.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSTTKKRKL GKNPDVDTSF LPDRDREEEE NRLREELRQE WEAKQEKIKS EEIEITFSYW DGSGHRRTVK MRKGNTMQQF LQKALEILRK DFSELRSAGV EQLMYIKEDL IIPHHHSFYD FIVTKARGKS GPLFNFDVHD DVRLLSDATV EKDESHAGKV VLRSWYEKNK HIFPASRWEP YDPEKKWDKY TIR.
Product Science Overview
Gene and Protein Information
- Gene Name: FAM50A
- Aliases: XAP5, HXC-26, DXS9928E
- Protein Name: FAM50A protein, also known as XAP-5 or HXC26
- Chromosomal Location: X chromosome (Xq28)
- Gene Ontology (GO) Annotations: RNA binding
Function and Characteristics
The FAM50A gene encodes a basic protein that contains a nuclear localization signal, suggesting its role in the nucleus. It is believed to function as a DNA-binding protein or a transcriptional factor . The protein is probably involved in the regulation of pre-mRNA splicing, which is a crucial step in the processing of mRNA before it is translated into proteins .
Associated Diseases
Mutations or dysregulation of the FAM50A gene have been associated with several disorders, including:
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