FAM49B Human

Family with Sequence Similarity 49, Member B Human Recombinant
Cat. No.
BT8099
Source
E.coli.
Synonyms
BM-009, L1, Protein FAM49B, FAM49B.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

FAM49B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 347amino acids (1-324 a.a) and having a molecular mass of 39.1kDa. FAM49B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
As a member of the FAM49 family, Family with Sequence Similarity 49, Member B (FAM49B) has been identified in recent genome-wide transcriptional analyses as part of a gene signature for multiple sclerosis (MS). This signature notably reverts to normal during pregnancy, particularly for seven genes, including FAM49B. These genes, predominantly negative regulators of inflammation, are: SOCS2, TNFAIP3, NR4A2, CXCR4, POLR2J, FAM49B, and STAG3L1.
Description
Recombinant FAM49B Human, produced in E.Coli, is a single, non-glycosylated polypeptide chain. This protein consists of 347 amino acids (with a sequence of 1-324 a.a), resulting in a molecular mass of 39.1kDa. For purification purposes, FAM49B is tagged with a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
The product appears as a clear, colorless solution that has been sterilized through filtration.
Formulation
The FAM49B protein solution is provided at a concentration of 1mg/ml and is prepared in a buffer solution containing 20mM Tris-HCl (pH 8.0), 10% glycerol, 0.1M NaCl, and 1mM DTT.
Stability
For short-term storage (2-4 weeks), the product should be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. Adding a carrier protein (0.1% HSA or BSA) is advised for long-term storage. To maintain product integrity, avoid repeated freeze-thaw cycles.
Purity
The purity of the FAM49B protein is greater than 90%, as determined by SDS-PAGE analysis.
Synonyms
BM-009, L1, Protein FAM49B, FAM49B.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGNLLKV LTCTDLEQGP NFFLDFENAQ PTESEKEIYN QVNVVLKDAE GILEDLQSYR GAGHEIREAI QHPADEKLQE KAWGAVVPLV GKLKKFYEFS QRLEAALRGL LGALTSTPYS PTQHLEREQA LAKQFAEILH FTLRFDELKM TNPAIQNDFS YYRRTLSRMR INNVPAEGEN EVNNELANRM SLFYAEATPM LKTLSDATTK FVSENKNLPI ENTTDCLSTM ASVCRVMLET PEYRSRFTNE ETVSFCLRVM VGVIILYDHV HPVGAFAKTS KIDMKGCIKV LKDQPPNSVE GLLNALRYTT KHLNDETTSK QIKSMLQ.

Product Science Overview

Discovery and Structure

FAM49B was identified through genome-wide transcriptional analysis. It is a member of the FAM49 family, which includes proteins with sequence similarities that suggest shared functional characteristics. The structure of FAM49B includes domains that are crucial for its interaction with other cellular components, particularly in the regulation of signaling pathways.

Biological Function

One of the primary functions of FAM49B is its role as a negative regulator of T cell receptor (TCR) signaling. This protein has been shown to suppress Rac-1 activity in vitro, which is essential for the regulation of T cell development and function . Specifically, FAM49B dampens TCR signal strength to regulate the survival of positively selected thymocytes and peripheral T cells. This regulation is crucial for ensuring the proper development and function of the immune system .

Role in Disease

Recent studies have highlighted the potential role of FAM49B in various diseases. For instance, a gene signature involving FAM49B was identified in multiple sclerosis (MS), which reverted to normal levels during pregnancy . This suggests that FAM49B may play a role in the pathogenesis of MS and potentially other autoimmune diseases.

Research and Applications

The recombinant form of FAM49B (Human Recombinant) is used in various research applications to study its function and potential therapeutic implications. By using recombinant proteins, researchers can investigate the specific interactions and pathways involving FAM49B in a controlled environment. This has led to a better understanding of its role in immune regulation and its potential as a therapeutic target.

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THE BIOTEK
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