FABP9 Human

Fatty Acid Binding Protein-9 (FABP9), also known as Testis-type Fatty Acid Binding Protein (T-FABP), is a member of the fatty acid-binding protein family. These proteins are involved in the intracellular transport of fatty acids and other lipophilic substances. FABP9 is specifically expressed in the testis and plays a crucial role in lipid metabolism and spermatogenesis.

The FABP9 gene is located on chromosome 8 and encodes a protein consisting of 132 amino acids . The human recombinant version of FABP9 is produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain containing 156 amino acids, including a 24 amino acid His-tag at the N-terminus . The molecular mass of this recombinant protein is approximately 17.6 kDa .

FABP9 is predicted to enable lipid binding activity and is involved in acrosome assembly, a critical process in sperm development . The protein is primarily located in the cytosol and is highly expressed in the internal root sheath of hair follicles . It is also enriched in the skin, cerebral cortex, cerebellum, and other tissues .

FABP9 is associated with several metabolic pathways, including triglyceride metabolism and general lipid metabolism . The protein’s ability to bind and transport fatty acids is essential for maintaining cellular lipid homeostasis and supporting various physiological processes.

While the specific clinical implications of FABP9 are still under investigation, its role in lipid metabolism and spermatogenesis suggests potential relevance in reproductive health and metabolic disorders. Understanding the function and regulation of FABP9 could provide insights into the development of therapeutic strategies for related conditions.