FABP9 Antibody
Description
Product Specs
Product Science Overview
Fatty Acid Binding Proteins (FABPs) are a family of intracellular lipid-binding proteins that play a crucial role in the transport and metabolism of fatty acids and other lipophilic substances within cells. These proteins are highly conserved across species and are involved in various cellular processes, including lipid signaling, metabolism, and inflammation .
FABPs are small, cytosolic proteins characterized by a water-filled binding pocket surrounded by ten anti-parallel beta sheets, forming a beta barrel structure. This structure is capped by two alpha-helices at the superior surface, which regulate ligand binding . FABPs have broad specificity and can bind long-chain fatty acids, eicosanoids, bile salts, and peroxisome proliferators .
FABPs demonstrate strong evolutionary conservation and are present in a wide range of species, including Drosophila melanogaster, Caenorhabditis elegans, mice, and humans . The human genome contains nine putatively functional protein-coding FABP genes, each with distinct tissue expression profiles .
FABP9, also known as testis-FABP (T-FABP), is one of the lesser-studied members of the FABP family. It is predominantly expressed in the testis but may also be found in other tissues . The specific functions and ligand-binding properties of FABP9 are still under investigation, but it is believed to play a role in lipid metabolism and signaling within the testis.
Mouse anti-human FABP9 antibodies are monoclonal antibodies developed to specifically recognize and bind to human FABP9. These antibodies are used in various research applications, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA). They are valuable tools for studying the expression, localization, and function of FABP9 in different biological contexts.
Understanding the role of FABP9 in lipid metabolism and signaling can provide insights into various physiological and pathological processes. Research on FABP9 may contribute to the development of therapeutic strategies for conditions related to lipid metabolism, such as obesity, diabetes, and cardiovascular diseases .
