FABP7 Human
Fatty Acid Binding Protein-7 Human Recombinant
Cat. No.
BT7369
Source
Escherichia Coli.
Synonyms
MRG, BLBP, FABPB, B-FABP, DKFZp547J2313, Fatty acid-binding protein brain, Fatty acid-binding protein 7, Brain lipid-binding protein, Mammary-derived growth inhibitor related, FABP7.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
FABP7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 14 kDa.
Product Specs
Introduction
Brain fatty acid binding protein (FABP7) belongs to the family of fatty acid binding proteins (FABPs), which are small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. These proteins play crucial roles in fatty acid uptake, transport, and metabolism. FABP7 is found in radial glia upon activation by Notch receptors. Among all FABPs, FABP7 exhibits the highest affinity for docosahexaenoic acid (DHA). It is essential for transporting hydrophobic ligands, potentially with morphogenic activity, during central nervous system (CNS) development. Notably, FABP7 is crucial for establishing the radial glial fiber system in the developing brain, a system vital for immature neurons to migrate and form cortical layers (similar to other FABPs).
Description
Recombinant human FABP7, expressed in E. coli, is a single polypeptide chain without glycosylation. It consists of 132 amino acids, resulting in a molecular weight of 14 kDa.
Physical Appearance
The product appears as a clear, colorless solution after sterile filtration.
Formulation
The FABP7 protein is supplied in a solution containing 25mM Tris-HCl at pH 7.5, 2mM EDTA, and 10% Glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein like 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freeze-thaw cycles to maintain protein integrity.
Purity
The purity of FABP7 is determined to be greater than 95.0% using SDS-PAGE analysis.
Synonyms
MRG, BLBP, FABPB, B-FABP, DKFZp547J2313, Fatty acid-binding protein brain, Fatty acid-binding protein 7, Brain lipid-binding protein, Mammary-derived growth inhibitor related, FABP7.
Source
Escherichia Coli.
Amino Acid Sequence
MVEAFCATWK LTNSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDKV VIRTLSTFKN TEISFQLGEE FDETTADDRN CKSVVSLDGD KLVHIQKWDG KETNFVREIK DGKMVMTLTF GDVVAVRHYE KA.
Product Science Overview
Classification and Structure
Biological Properties and Functions
FABP7 is predominantly expressed in the brain, particularly in radial glial cells during development . It is involved in the uptake, transport, and metabolism of fatty acids, which are essential for brain development and function . FABP7 has a high affinity for docosahexaenoic acid (DHA), an omega-3 fatty acid crucial for neural development .
Mode of Action
Regulatory Mechanisms
Role in Pathology
FABP7 has been implicated in various neurological disorders. For instance, it has been associated with schizophrenia, as it maps onto a schizophrenia linkage region on chromosome 6 . Additionally, FABP7 expression is altered in certain types of brain tumors and other central nervous system diseases .
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