FABP7 Antibody

Fatty Acid Binding Protein-7, also known as Brain lipid-binding protein, is a member of the intracellular lipid-binding protein family. This protein plays a crucial role in the uptake and intracellular transport of fatty acids and is particularly important in brain development and function.

Fatty Acid Binding Protein-7 is primarily expressed in astrocytes and radial glia-like cells within the adult central nervous system. It is involved in the regulation of lipid metabolism, energy homeostasis, and inflammation. The protein binds to long-chain fatty acids and other hydrophobic ligands, facilitating their transport within the cell.

Fatty Acid Binding Protein-7 has been implicated in various neurological conditions. For instance, its expression is upregulated in Alzheimer’s disease, where it contributes to neuroinflammation. Studies have shown that treatment of primary hippocampal astrocyte cultures with amyloid beta fragment induces the upregulation of Fatty Acid Binding Protein-7. This upregulation is also observed in the brains of Alzheimer’s disease patients and mouse models .

In multiple system atrophy, a rare neurodegenerative disease, inhibition of Fatty Acid Binding Protein-7 has been shown to reduce alpha-synuclein aggregation and improve motor function in mouse models .

Research on Fatty Acid Binding Protein-7 has led to the development of specific inhibitors that can counteract its effects in disease models. For example, the pharmacological inhibition of Fatty Acid Binding Protein-7 by a compound known as MF 6 has shown promising results in reducing cerebellar dysfunction in multiple system atrophy mouse models .