FABP3 Paired Antibody
Fatty acid-binding protein heart, H-FABP, Heart-type fatty acid-binding protein, Muscle fatty acid-binding protein, M-FABP, Mammary-derived growth inhibitor, MDGI, FABP3, FABP11, O-FABP.
2 vials of sterile Filtered clear colorless solution.
Greater than 95%.
Description
FABP3 gold conjugation antibody and FABP3 capture antibody are used to develop rapid test for FABP3 rapid test. Please note that when ordering for example: 50µg antibody we ship 25µg from each of the antibodies (50µg in total).
Product Specs
Fatty acid-binding protein heart, H-FABP, Heart-type fatty acid-binding protein, Muscle fatty acid-binding protein, M-FABP, Mammary-derived growth inhibitor, MDGI, FABP3, FABP11, O-FABP.
Purified monoclonal IgG by protein A chromatography.
Product Science Overview
Fatty acid binding proteins (FABPs) are a family of small, highly conserved cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. They play a crucial role in the intracellular transport of fatty acids, their metabolism, and signaling. Among the various types of FABPs, Fatty Acid Binding Protein 3 (FABP3), also known as Heart-type Fatty Acid Binding Protein (H-FABP), is predominantly expressed in the heart, skeletal muscle, brain, and mammary gland .
FABP3 is essential for the transport of fatty acids to mitochondria for β-oxidation, a process that generates energy. It also plays a role in the regulation of cell growth and differentiation. The release of FABP3 from the heart into the bloodstream is used as a biomarker for myocardial infarction and other forms of cardiac stress . Additionally, FABP3 has been implicated in various diseases, including cancer and neurodegenerative disorders .
The Mouse Anti-Human FABP3 antibody is a monoclonal antibody that specifically binds to human FABP3. This antibody is produced by immunizing mice with the full-length human FABP3 protein, leading to the generation of a highly specific immune response . The antibody is typically of the IgG1 isotype and is used in various applications, including immunohistochemistry (IHC), Western blotting, and immunoprecipitation .
- Immunohistochemistry (IHC): The Mouse Anti-Human FABP3 antibody is widely used in IHC to detect FABP3 expression in tissue samples. This application is particularly useful in identifying ischemic areas in the human heart and as a marker for brain damage .
- Western Blotting: In Western blotting, the antibody helps in the detection and quantification of FABP3 protein levels in various biological samples. This is crucial for research studies focusing on cardiac health and disease .
- Immunoprecipitation: The antibody is also used in immunoprecipitation assays to isolate and study FABP3 protein interactions and functions .
Research studies have demonstrated differential FABP3 expression in several types of tumors and their normal-cell counterparts . FABP3 may act as a potential tumor suppressor in breast cancer and is involved in the propagation of α-Synuclein in neurodegenerative diseases . The Mouse Anti-Human FABP3 antibody is a valuable tool in these research areas, providing insights into the molecular mechanisms underlying these diseases.
