FABP1 Antibody

Fatty Acid Binding Protein-1 (FABP1) is a member of the intracellular lipid-binding protein (iLBP) family. These proteins are involved in the reversible binding of intracellular hydrophobic ligands and their trafficking throughout cellular compartments, including peroxisomes, mitochondria, endoplasmic reticulum, and the nucleus . FABP1 is ubiquitously expressed in tissues that are highly active in fatty acid metabolism, such as the liver, intestine, and kidney .

FABP1 is a small, structurally conserved cytosolic protein consisting of a water-filled, interior-binding pocket surrounded by ten anti-parallel beta sheets, forming a beta barrel . At the superior surface, two alpha-helices cap the pocket and are thought to regulate binding . FABP1 has broad specificity, including the ability to bind long-chain fatty acids, eicosanoids, bile salts, and peroxisome proliferators .

FABP1 demonstrates strong evolutionary conservation and is present in a spectrum of species, including Drosophila melanogaster, Caenorhabditis elegans, mouse, and human . The human genome consists of nine putatively functional protein-coding FABP genes, with FABP1 being one of the most studied .

Recent studies have shown that FABP1 plays a significant role in various diseases, including hepatocellular carcinoma (HCC). FABP1 is overexpressed in tumor-associated macrophages (TAMs) in HCC tissues, and its deficiency in TAMs inhibits HCC progression . FABP1 interacts with peroxisome proliferator-activated receptor gamma (PPARG) in TAMs to promote fatty acid oxidation and the progression of HCC .

Mouse anti-human FABP1 antibodies are used in research to study the expression and function of FABP1 in human tissues. These antibodies are crucial for immunohistochemistry, Western blotting, and other immunoassays to detect FABP1 in various biological samples. They help in understanding the role of FABP1 in different physiological and pathological conditions.