ERBB2 Antibody

Herstatin is a product of an alternative transcript of the HER-2/neu (erbB-2) gene, which encodes an 185-kDa orphan receptor tyrosine kinase. This receptor is constitutively active as a dimer and displays potent oncogenic activity when overexpressed . Herstatin retains intron 8 of the HER-2 gene, leading to the production of a unique protein that plays a significant role in inhibiting the oncogenic activity of p185HER-2 .

Herstatin mRNA is expressed in normal human fetal kidney and liver tissues but is found at reduced levels in carcinoma cells that contain an amplified HER-2 gene . Herstatin functions as an inhibitor of p185HER-2 by disrupting dimers, reducing tyrosine phosphorylation of p185, and inhibiting the anchorage-independent growth of transformed cells that overexpress HER-2 .

The Mouse Anti Human Herstatin antibody is a monoclonal antibody derived from mice immunized with recombinant human ErbB2 . This antibody is used in various scientific applications, including ELISA, Western blotting, immunohistochemistry, and flow cytometry . The antibody is lyophilized in a phosphate buffer and remains stable and fully active when stored at -20°C .

The Mouse Anti Human Herstatin antibody is used to detect Her-2 (ErbB2) in human, mouse, rat, canine, and non-human primate samples . It is recommended to reconstitute the lyophilized antibody with deionized water and store it at -80°C to avoid repeated freezing/thawing cycles . The reconstituted antibody can be stored at 4°C for a limited period without a decline in activity .