EPHA2 PAT66G9AT Antibody

EPH receptor A2 PAT66G9AT, Mouse Anti Human
Cat. No.
BT17002
Source
Synonyms
EPHA2, EPH Receptor A2, ECK, Tyrosine-Protein Kinase Receptor ECK, EC 2.7.10.1, CTRCT6, ARCC2, CTPP1, CTPA, Epithelial Cell Receptor Protein Tyrosine Kinase, Ephrin Type-A Receptor 2, Soluble EPHA2 Variant 1, Epithelial Cell Kinase, EC 2.7.10, EphA2.
Appearance
Sterile filtered colorless solution.
Purity
Usage
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Description

Product Specs

Introduction
EPH Receptor A2 (EPHA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPHA2 binds ephrin-A ligands. EPH and EPH-related receptors mediate developmental events, particularly in the nervous system. EPH subfamily receptors typically possess a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. The ephrin receptors are grouped based on their extracellular domain sequence similarity and binding affinities for ephrin-A and ephrin-B ligands. EPHA2 gene mutations cause certain genetically-related cataract disorders.
Physical Appearance
Colorless, sterile-filtered solution.
Formulation
1 mg/ml in PBS, pH 7.4, with 10% glycerol and 0.02% sodium azide.
Storage Procedures
Store at 4°C for up to 1 month. For longer storage, store at -20°C. Avoid freeze-thaw cycles.
Stability / Shelf Life
12 months at -20°C. 1 month at 4°C.
Applications
This antibody has been validated for ELISA, Western blot analysis, flow cytometry, and ICC/IF to ensure specificity and reactivity. However, optimal working dilutions should be determined for each application.
Synonyms
EPHA2, EPH Receptor A2, ECK, Tyrosine-Protein Kinase Receptor ECK, EC 2.7.10.1, CTRCT6, ARCC2, CTPP1, CTPA, Epithelial Cell Receptor Protein Tyrosine Kinase, Ephrin Type-A Receptor 2, Soluble EPHA2 Variant 1, Epithelial Cell Kinase, EC 2.7.10, EphA2.
Purification Method
EPHA2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT66G9AT.
Immunogen
Anti-human EPHA2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EPHA2 protein 27-537 amino acids purified from E. coli.
Ig Subclass
Mouse IgG2b heavy chain and k light chain.

Product Science Overview

Overview of EPHA2

EPHA2 is involved in numerous cellular processes and has been implicated in the progression of various cancers. It is known to influence cell morphology and motility by interacting with its ephrin ligands, which are membrane-bound proteins. The binding of ephrin ligands to EPHA2 triggers bidirectional signaling, affecting both the receptor-expressing and ligand-expressing cells.

PAT66G9AT Antibody

The PAT66G9AT is a mouse monoclonal antibody specifically designed to target the human EPHA2 receptor. This antibody is produced by hybridizing mouse F0 myeloma cells with spleen cells from BALB/c mice that have been immunized with human EPHA2 . The resulting hybridoma cells produce the PAT66G9AT antibody, which can be used in various applications such as Western Blotting (WB), Immunocytochemistry (ICC), and Immunofluorescence (IF) .

Applications and Importance

The PAT66G9AT antibody is widely used in research to study the expression and function of EPHA2 in different cell types and tissues. It is particularly valuable in cancer research, where EPHA2 is often overexpressed and associated with tumor progression and metastasis. By using this antibody, researchers can investigate the role of EPHA2 in cancer and potentially develop targeted therapies.

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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