Endoglin (27-581) Mouse
Description
Endoglin is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The recombinant mouse Endoglin (27-581) is a specific fragment of the full-length protein. It is expressed in Sf9 Baculovirus cells and consists of a single, glycosylated polypeptide chain containing 563 amino acids (27-581 a.a.) . The molecular weight of this recombinant protein is approximately 60.9 kDa, although it migrates at 50-70 kDa on SDS-PAGE under reducing conditions .
Endoglin functions as a co-receptor for transforming growth factor-beta (TGF-β) and is involved in the regulation of cell proliferation, differentiation, and migration. It is particularly important in the context of endothelial cells, where it modulates the TGF-β signaling pathway to promote angiogenesis. This makes Endoglin a critical player in both normal vascular development and in pathological conditions such as tumor growth and metastasis.
Mutations in the Endoglin gene (ENG) are associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder that leads to abnormal blood vessel formation. Patients with HHT often experience frequent nosebleeds, gastrointestinal bleeding, and arteriovenous malformations. Due to its role in angiogenesis, Endoglin is also a target for anti-angiogenic therapies in cancer treatment.
Recombinant Endoglin (27-581) is used in various research applications, including:
- Studying TGF-β signaling pathways: Researchers use this recombinant protein to investigate how Endoglin interacts with TGF-β and other signaling molecules.
- Angiogenesis research: Given its role in blood vessel formation, Endoglin is a valuable tool for studying angiogenesis in both normal and disease states.
- Drug development: Endoglin is a potential target for developing new therapies for cancer and other diseases involving abnormal angiogenesis.
