EBV p23

The Epstein-Barr Virus (EBV), also known as Human Herpesvirus 4 (HHV-4), is a member of the herpesvirus family. It is one of the most common viruses in humans, with approximately 90-95% of adults having been infected at some point in their lives . EBV is best known for causing infectious mononucleosis, commonly referred to as “mono” or "glandular fever" . However, it is also associated with several types of cancer, including Hodgkin’s lymphoma, Burkitt’s lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV .

The EBV p23 protein is a viral late complex associated with virion particles. It consists of two gene products, BFRF3 and BLRF2 . The p23 protein is a mosaic protein that contains regions from the HHV-4 p23 . This protein is crucial for the virus’s ability to infect and replicate within host cells.

Recombinant EBV p23 is an E. coli-derived protein that contains the HHV-4 p23 regions . This recombinant protein is used in various research applications, including as an antigen in ELISA and Western blots . It is highly pure, with a purity level of over 95% as determined by SDS-PAGE . The recombinant p23 protein is also tagged with six histidines at the C-terminus, which aids in its purification and detection .

The recombinant EBV p23 protein is widely used in research to study the virus’s structure and function. It is an excellent antigen for detecting HHV-4 (EBV) with minimal specificity problems . Researchers use this protein to generate antibodies that specifically target the p23 protein, which can be used in various diagnostic and therapeutic applications .