DYNLRB1 Human

Dynein Light Chain Roadblock-Type 1 acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex. This complex is responsible for the intracellular retrograde motility of vesicles and organelles along microtubules . The protein is involved in linking dynein to cargos and to adapter proteins that regulate dynein function .

The DYNLRB1 gene is located on chromosome 20 in humans and is known to produce multiple transcript variants through alternative splicing . The protein itself consists of 96 amino acids and has a molecular weight of approximately 11 kDa .

DYNLRB1 is expressed in various tissues, with high expression levels observed in the heart, liver, brain, and pancreas. Moderate expression is found in the placenta, skeletal muscle, and kidney, while low expression is seen in the lung, prostate, testis, small intestine, and colon . Notably, the expression of DYNLRB1 is up-regulated in a significant percentage of hepatocellular carcinoma (HCC) patients, suggesting a potential role in tumor progression .

The cytoplasmic dynein 1 complex, of which DYNLRB1 is a part, consists of two catalytic heavy chains and several non-catalytic subunits, including intermediate chains, light intermediate chains, and light chains . The composition of these subunits can vary, affecting the function and regulation of the dynein complex .

Mutations or dysregulation of the DYNLRB1 gene have been associated with various diseases, including developmental and epileptic encephalopathy 23 and sialolithiasis . The protein’s involvement in tumor progression, particularly in hepatocellular carcinoma, highlights its potential as a target for therapeutic interventions .