DYNLL1 Antibody

Dynein Light Chain LC8 Type-1 (DYNLL1), also known as DLC1, is a protein coding gene that plays a crucial role in intracellular transport and motility. It is a part of the cytoplasmic dynein complex, which is a large enzyme complex involved in the retrograde transport of vesicles and organelles along microtubules .

The cytoplasmic dynein complex consists of two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain containing a varying number of accessory intermediate chains. DYNLL1 acts as one of several non-catalytic accessory components of this complex . It is involved in linking dynein to cargos and adapter proteins that regulate dynein function .

DYNLL1 also physically interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). Binding of DYNLL1 destabilizes the nNOS dimer, a conformation necessary for its activity, thereby regulating numerous biological processes through its effects on nitric oxide synthase activity .

DYNLL1 is associated with several biological pathways, including:

• Loss of proteins required for interphase microtubule organization from the centrosome
• EML4 and NUDC in mitotic spindle formation

Mutations or dysregulation of DYNLL1 have been linked to various diseases, including:

• Enterokinase Deficiency
• Bardet-Biedl Syndrome

Research has shown that DYNLL1 plays important roles in the establishment of B-1a cells in the peritoneal cavity and in the ongoing development of B-2 lymphoid cells in the bone marrow of mice . Additionally, DYNLL1 regulates axonal mitochondrial mobility by binding to syntaphilin (SNPH), enhancing the SNPH-microtubule docking interaction .

Mouse anti-human DYNLL1 antibodies are used in various research applications to study the protein’s function and its role in different biological processes. These antibodies help in detecting and quantifying DYNLL1 in various experimental setups.