DUSP22 Human

DUSP22 plays a crucial role in various cellular processes by participating in multiple signaling cascades. It is known to activate the JNK signaling pathway and inactivate the tyrosine kinase Lck by dephosphorylating the tyrosine-394 residue during T cell receptor signaling . Additionally, DUSP22 dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), which are involved in stress response pathways .

DUSP22 is expressed in various tissues, with significant roles in immune cells. Dysregulation of DUSP22 has been associated with human lupus nephritis, highlighting its importance in immune regulation .

Recombinant Human DUSP22 is typically produced in Escherichia coli (E. coli) or wheat germ expression systems. The recombinant protein often includes a purification tag, such as a His-tag or GST-tag, to facilitate purification and detection . The recombinant protein is used in various research applications, including Western Blotting (WB), Enzyme-Linked Immunosorbent Assay (ELISA), and functional studies.

Recombinant Human DUSP22 is primarily used for research purposes to study its role in signaling pathways and its potential therapeutic applications. It is not approved for use in humans or clinical diagnosis .

Recombinant Human DUSP22 should be stored at -20°C for long-term storage and at 4°C for short-term storage. It is important to avoid repeated freeze-thaw cycles to maintain protein integrity .