DLX3 Human
Distal-Less Homeobox 3 Human Recombinant
Cat. No.
BT21646
Source
Escherichia Coli.
Synonyms
Homeobox protein DLX-3, DLX3, Distal-Less Homeobox 3, AI4, TDO.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTeks products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
DLX3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 209 amino acids (1-186 a.a) and having a molecular mass of 23.4kDa.
DLX3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
DLX3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
DLX3, a member of the Distal-less (Dlx) gene family, plays a crucial role in the development of the ventral forebrain, craniofacial patterning, and morphogenesis. This gene family comprises at least six members. Mutations in DLX3 are associated with Trichodentoosseous syndrome, an autosomal dominant condition. Located on the long arm of chromosome 17, DLX3 is positioned in a tail-to-tail configuration with another member of the same gene family.
Description
Recombinant human DLX3, produced in E. coli, is a single, non-glycosylated polypeptide chain. It encompasses 209 amino acids (specifically, amino acids 1-186), resulting in a molecular weight of 23.4 kDa. The protein is engineered with a 23 amino acid His-tag fused at the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that has undergone sterile filtration.
Formulation
The DLX3 protein solution is provided at a concentration of 1 mg/ml. It is formulated in a buffer containing 20 mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product should be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of the protein is greater than 85%, as determined by SDS-PAGE analysis.
Synonyms
Homeobox protein DLX-3, DLX3, Distal-Less Homeobox 3, AI4, TDO.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSGSFDR KLSSILTDIS SSLSCHAGSK DSPTLPESSV TDLGYYSAPQ HDYYSGQPYG QTVNPYTYHH QFNLNGLAGT GAYSPKSEYT YGASYRQYGA YREQPLPAQD PVSVKEEPEA EVRMVNGKPK KVRKPRTIYS SYQLAALQRR FQKAQYLALP ERAELAAQLG LTQTQVKIWF QNRRSKFKK.
Product Science Overview
Evolutionary Background
The Dlx gene family is evolutionarily conserved and is related to the Distal-less (Dll) gene found in the fruit fly, Drosophila melanogaster. The Dll gene is crucial for the development of the head and limbs in fruit flies . In vertebrates, the Dlx family comprises at least six members: DLX1 to DLX6 .
Genetic and Molecular Characteristics
Biological Functions
Recombinant DLX3 Protein
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