DKK2 Human

Dickkopf-Related Protein 2 (DKK2) is a member of the Dickkopf family of proteins, which are known for their role in modulating the Wnt signaling pathway. The Wnt signaling pathway is crucial for various developmental processes, including cell proliferation, differentiation, and migration. DKK2, in particular, has been implicated in embryonic development and various physiological processes in adults.

DKK2 is a secreted protein that contains two conserved cysteine-rich domains separated by a linker region . These domains are essential for its interaction with Wnt co-receptors, such as LRP5/6, and other modulatory proteins like Kremen 2. Depending on the cellular context and the presence of co-factors, DKK2 can function as either an agonist or antagonist of the Wnt/β-catenin signaling pathway .

During embryonic development, DKK2 plays a vital role in processes such as antero-posterior axial patterning, limb development, somitogenesis, and eye formation . By modulating the Wnt signaling pathway, DKK2 ensures the proper formation and differentiation of tissues and organs.

DKK2 is expressed in various tissues, including the heart, brain, skeletal muscle, and lung . Its expression is tightly regulated to ensure proper developmental and physiological outcomes. Dysregulation of DKK2 expression has been linked to various diseases, including bone disorders, cancer, and neurodegenerative diseases .

Recombinant human DKK2 is produced using advanced biotechnological methods to ensure high purity and activity. This recombinant protein is used in various research applications to study its role in development and disease. It is also utilized in drug discovery and development processes to identify potential therapeutic targets and interventions .