Dengue NS1, ST4
Description
Product Specs
Purified by proprietary chromatographic technique.
Product Science Overview
Dengue virus (DENV) is a mosquito-borne virus that causes dengue fever, a significant global health concern. The virus belongs to the Flaviviridae family and has four serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Each serotype is antigenically distinct, meaning that infection with one serotype does not confer immunity against the others .
The dengue virus genome encodes three structural proteins (capsid, pre-membrane, and envelope) and seven non-structural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5). Among these, NS1 is a glycoprotein that plays a crucial role in viral replication and immune evasion. It is secreted into the bloodstream during infection and can be detected in the early stages of dengue fever .
Recombinant NS1 proteins are produced using genetic engineering techniques to express the NS1 protein in various host systems, such as bacteria, yeast, or mammalian cells. These recombinant proteins are used in diagnostic tests and vaccine development due to their ability to elicit an immune response .
The NS1 protein of DENV-4 is particularly important for diagnostic and research purposes. It has been observed that many commercially available NS1 antigen tests have limited sensitivity to DENV-4 compared to other serotypes. Therefore, developing specific monoclonal antibodies and diagnostic tests for DENV-4 NS1 is crucial .
- Diagnostic Tests: Recombinant NS1 proteins are used in enzyme-linked immunosorbent assays (ELISAs) to detect dengue virus infections. These tests can identify the presence of NS1 in patient samples, providing early diagnosis of dengue fever .
- Vaccine Development: Recombinant NS1 proteins are also being explored as potential vaccine candidates. They can be formulated with adjuvants to enhance their immunogenicity and provide protection against dengue virus infection .
