Dengue Envelope-4 22kDa
Description
Product Specs
Purified by proprietary chromatographic technique.
Product Science Overview
Dengue virus (DENV) is a mosquito-borne virus that infects millions of people annually across more than 120 countries . The virus is classified into four distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Each serotype can cause dengue fever, which can escalate into severe dengue, leading to hemorrhagic fever and potentially fatal outcomes .
The dengue virus is an RNA virus belonging to the Flaviviridae family. The viral genome encodes three structural proteins: the capsid ©, membrane (M), and envelope (E) proteins, along with seven non-structural proteins . The envelope protein (E) is crucial for virus entry into host cells and is a primary target for neutralizing antibodies .
DENV-4 is one of the four serotypes of the dengue virus. It shares many structural similarities with the other serotypes but has unique antigenic properties that distinguish it from the others . The envelope protein of DENV-4 plays a significant role in the virus’s ability to infect host cells and elicit an immune response.
The recombinant envelope protein of DENV-4, specifically the 22kDa fragment, is a genetically engineered peptide derived from the envelope protein of the virus . This recombinant protein is often produced in E. coli and includes a 6xHis tag for purification purposes . The 22kDa fragment contains epitopes that are recognized by the immune system, making it a valuable tool for research and vaccine development.
- Vaccine Development: The recombinant envelope protein is used in the development of vaccines against dengue. By understanding the immune response to this protein, researchers can design vaccines that elicit strong and protective immunity.
- Diagnostic Tools: The 22kDa recombinant protein can be used in diagnostic assays to detect antibodies against DENV-4 in patient samples. This helps in the accurate diagnosis of dengue infections.
- Research: Studying the recombinant envelope protein provides insights into the structure and function of the dengue virus. It helps in understanding how the virus interacts with host cells and evades the immune system.
