CTBP1 Antibody
Description
Product Specs
Product Science Overview
C-Terminal Binding Protein 1, also known as CtBP1, is a transcriptional co-repressor that plays a significant role in various cellular processes, including gene regulation, cell survival, and development. The monoclonal mouse anti-human antibody targeting CtBP1 is a crucial tool in biomedical research, particularly in the study of cancer and other diseases where CtBP1 is implicated.
CtBP1 belongs to the hydroxyacid-dehydrogenase family and possesses a NAD(H)-binding Rossmann fold. This structural feature is essential for its function as it allows CtBP1 to oligomerize and interact with various protein partners. CtBP1 acts as a transcriptional co-repressor by binding to specific DNA sequences and recruiting other proteins to form a repressive complex. This complex inhibits the transcription of target genes, thereby regulating various cellular processes.
CtBP1 is overexpressed in multiple cancers and has pro-tumorigenic functions. It regulates gene networks associated with cancer hallmarks, such as increased cell survival, proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). By repressing the expression of tumor suppressor genes and promoting the expression of oncogenes, CtBP1 contributes to the malignant behavior of cancer cells .
The monoclonal mouse anti-human antibody targeting CtBP1 is developed to specifically bind to the human CtBP1 protein. This antibody is produced by immunizing mice with human CtBP1 protein, followed by the isolation and cloning of specific B cells that produce the desired antibody. The monoclonal nature of the antibody ensures high specificity and affinity for the target protein, making it a valuable tool for research and therapeutic applications.
- Cancer Research: The monoclonal mouse anti-human CtBP1 antibody is widely used in cancer research to study the role of CtBP1 in tumorigenesis. It helps in identifying the expression levels of CtBP1 in various cancer types and understanding its contribution to cancer progression.
- Gene Regulation Studies: Researchers use this antibody to investigate the mechanisms by which CtBP1 regulates gene expression. By identifying the target genes and interacting partners of CtBP1, scientists can gain insights into the complex regulatory networks controlled by this protein.
- Drug Development: The antibody serves as a tool for screening potential inhibitors of CtBP1. By targeting the CtBP1 protein, researchers aim to develop novel therapeutic strategies for cancers and other diseases where CtBP1 plays a critical role.
