CSNK2B Protein

The CK2b subunit is a 26 kDa protein that primarily serves regulatory functions . It interacts with the catalytic α-subunits to modulate the kinase’s activity and substrate specificity . The CK2b subunit is also involved in the stabilization of the holoenzyme complex and influences its localization within the cell .

CK2 is known for its constitutive activity, meaning it is active without the need for additional regulatory signals . This kinase is involved in a wide range of cellular processes, including:

• Cell growth and division: CK2 phosphorylates various nuclear proteins involved in DNA metabolism, transcription factors, and oncogenes .
• Signal transduction: It plays a pivotal role in activating pathways such as the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) and nuclear factor kappa B (NF-κB) pathways .
• Differentiation and development: CK2 is involved in processes like osteogenesis, adipogenesis, chondrogenesis, neuron differentiation, and immune response pathways .

CK2 is highly expressed in different hematological malignancies, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) . Its role in these diseases makes it a potential target for therapeutic interventions.

Recombinant human CK2b is often produced in E. coli for research purposes . This recombinant protein is used to study the kinase’s function, screen for inhibitors, and investigate its role in various cellular processes .

In summary, Casein Kinase 2b (Human Recombinant) is a vital regulatory subunit of CK2, involved in numerous cellular functions and pathways. Its significance in cell growth, signal transduction, and disease makes it a critical focus of biomedical research.