CSNK2B Human

Casein Kinase 2 beta Human Recombinant
Cat. No.
BT30221
Source

Escherichia Coli.

Synonyms

PKCK2 Beta, PKCK2B, CK2N, CSK2B, MGC138222, MGC138224, G5A, Phosvitin, Casein Kinase 2 beta, Casein Kinase 2B, Casein Kinase 2 beta, Casein kinase 2 beta polypeptide, Casein kinase II subunit beta, CK II beta, CK2B, CSNK 2B, CSNK2B, G5A

Appearance
Sterile Filtered colorless solution.
Purity

Greater than 95.0% as determined by SDS-PAGE.

Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

CSNK2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids (1-215 a.a) and having a molecular mass of 24.9 kDa.
CSNK2B is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Casein Kinase 2 beta (CSNK2B) is a ubiquitous Ser/Thr kinase expressed in all eukaryotes. CSNK2B is a tetramer comprised of 2 catalytic kinase domains, alpha subunits and 2 identical regulatory beta subunits. CSNK2B takes part in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. The beta subunit itself confers stability to the CK2 alpha subunit and is involved in activity and substrate specificity but does not have kinase activity.
Description
CSNK2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 215 amino acids (1-215 a.a) and having a molecular mass of 24.9 kDa. CSNK2B is purified by proprietary chromatographic techniques.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CSNK2B protein solution (1mg/ml) in 0.2M NaCl, 20mM Tris-HCl buffer (pH 8.0), 1mM EDTA, 1mM DTT and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms

PKCK2 Beta, PKCK2B, CK2N, CSK2B, MGC138222, MGC138224, G5A, Phosvitin, Casein Kinase 2 beta, Casein Kinase 2B, Casein Kinase 2 beta, Casein kinase 2 beta polypeptide, Casein kinase II subunit beta, CK II beta, CK2B, CSNK 2B, CSNK2B, G5A

Source

Escherichia Coli.

Amino Acid Sequence

MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR

Product Science Overview

Gene and Protein Information

The CSNK2B gene is located on chromosome 6 at the cytoband p21.33 . This gene encodes the beta subunit of CK2, which is involved in regulating the basal catalytic activity of the alpha subunit . The beta subunit is essential for the stability and function of the CK2 holoenzyme .

Function and Biological Role

Casein Kinase 2 Beta is involved in several critical cellular functions, including:

  • Regulation of Metabolic Pathways: CK2 phosphorylates various nuclear proteins involved in DNA metabolism, transcription factors, and oncogenes, thereby influencing their activity .
  • Signal Transduction: CK2 plays a pivotal role in signal transduction pathways, including the Wnt signaling pathway .
  • Transcription and Translation: CK2 is involved in the regulation of transcription and translation processes .
  • Cell Growth and Division: CK2 is crucial for cell growth and division, making it an important player in cellular proliferation .
Recombinant Production

Human Recombinant Casein Kinase 2 Beta is produced using recombinant DNA technology, typically in Escherichia coli (E. coli) . This allows for the production of large quantities of the protein for research and therapeutic purposes.

Clinical and Research Implications

CK2 has been implicated in various diseases, including cancer and neurodevelopmental disorders . The study of CK2 and its subunits, including CSNK2B, is essential for understanding these diseases and developing potential therapeutic interventions.

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Source
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