TSLPR Antibody

Thymic Stromal Lymphopoietin (TSLP) is a cytokine that plays a crucial role in the immune system, particularly in the regulation of T helper (Th) 2 immune responses. It is primarily expressed by epithelial cells and has been implicated in various allergic and inflammatory diseases, as well as in the progression of certain cancers .

TSLP was originally discovered in conditioned media of a unique thymic stromal cell clone, Z210R.1, which supported the development of immature B cells and enhanced the proliferation of thymocytes . The receptor for TSLP, known as the Thymic Stromal Lymphopoietin Receptor (TSLPR), forms a high-affinity heteromeric complex with the interleukin-7 receptor alpha chain (IL-7Rα) .

TSLP exerts its biological effects by binding to the TSLPR-IL-7Rα complex, which activates downstream signaling pathways involved in immune cell proliferation, differentiation, and activation . TSLP is known to activate dendritic cells, promote Th2 differentiation of naïve CD4+ T cells, and activate natural killer T cells, basophils, and other innate immune cells .

TSLP-induced Th2 responses are associated with the pathogenesis of allergic inflammatory diseases, including atopic dermatitis, asthma, and rhinitis . Additionally, TSLP has been implicated in the pathogenesis of inflammatory bowel disease and the progression of certain cancers .

Mouse anti-human TSLPR antibodies are used in research to study the function and signaling of TSLPR in human cells. These antibodies are typically generated by immunizing mice with human TSLPR protein, followed by the isolation and characterization of specific antibodies that bind to human TSLPR. These antibodies can be used in various applications, including flow cytometry, immunohistochemistry, and functional assays, to investigate the role of TSLPR in human immune responses and diseases.