CREG1 Mouse
Protein CREG1, Cellular repressor of E1A-stimulated genes 1, Creg1, Creg.
Description
CREG1 Mouse Recombinant produced in E. coli is a single polypeptide chain containing 213 amino acids (32-220) and having a molecular mass of 24kDa. CREG1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Recombinant CREG1 Mouse protein, expressed in E. coli, is a single polypeptide chain with a molecular weight of 24kDa. It encompasses 213 amino acids, spanning from position 32 to 220. This protein is engineered with a 24 amino acid His-tag fused to its N-terminus and is purified using proprietary chromatographic techniques.
The CREG1 solution is provided at a concentration of 1mg/ml and is formulated in a buffer consisting of 20mM Tris-HCl (pH 8.0), 10% glycerol, and 0.15M NaCl.
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advisable for long-term storage.
Repeated freezing and thawing of the product should be avoided.
Protein CREG1, Cellular repressor of E1A-stimulated genes 1, Creg1, Creg.
MGSSHHHHHH SSGLVPRGSH MGSMRGGRDH GDWDVDRRLP PLPPREDGPR VARFVTHVSD WGSLATISTI KEVRGWPFAD IISISDGPPG EGTGEPYMYL SPLQQAVSDL QENPEATLTM SLAQTVYCRN HGFDPQSPLC VHIMMSGTVT KVNKTEEDYA RDSLFVRHPE MKHWPSSHNW FFAKLKISRI WVLDYFGGPK VVTPEEYFNV TLQ.
Product Science Overview
CREG1 is implicated in maintaining cellular homeostasis and has been shown to play a role in various physiological and pathological processes:
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Tumor Suppression: CREG1 has been identified as a tumor suppressor. It is negatively regulated by cathepsin proteases, particularly cathepsin B. Over-expression of cathepsin B reduces the abundance of CREG1, while inhibition or deletion of cathepsin B increases its levels . This regulation suggests that CREG1 plays a crucial role in tumor-stroma interactions and malignant cell behavior.
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Vascular Remodeling: CREG1 is a critical determinant of vascular remodeling in response to angiotensin II (Ang II). It has been shown that CREG gene expression is significantly decreased in remodeled vascular tissues of high salt-induced Dahl salt-sensitive rats and Ang II-induced mice . This downregulation is Ang II specific and independent of blood pressure. CREG1’s role in vascular remodeling highlights its potential as a therapeutic target for preventing vascular diseases.
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Cardiac Hypertrophy: CREG1 has been shown to attenuate cardiac hypertrophy in vitro. Although its role in vivo has not been fully determined, it is suggested that CREG1 could be beneficial in reducing cardiac hypertrophy .
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Cellular Senescence: CREG1 accelerates p16-dependent cellular senescence in vitro. It also stimulates brown adipogenesis, as observed in adipocyte P2-CREG1-transgenic (Tg) mice . This indicates that CREG1 may have a role in aging-associated phenotypes and metabolic processes.
Research on CREG1 continues to uncover its multifaceted roles in cellular processes. The recombinant form of CREG1, particularly in mouse models, has been instrumental in studying its functions and potential therapeutic applications. For instance, recombinant CREG1 has been used to reduce proliferation, migration, and invasion of tumor cells in vitro and in vivo .
In conclusion, Cellular Repressor of E1A-Stimulated Genes 1 (Mouse Recombinant) is a vital protein with significant implications in tumor suppression, vascular remodeling, cardiac hypertrophy, and cellular senescence. Its diverse roles make it a promising target for therapeutic interventions in various diseases.
