CREG1 Antibody

The Cellular Repressor of E1A-Stimulated Genes 1 (CREG1) is a secreted glycoprotein that plays a crucial role in regulating cellular proliferation and differentiation. Initially identified as a transcription factor, CREG1 has been shown to antagonize the transcriptional activation and cellular transformation induced by the adenovirus E1A oncoprotein . This protein is ubiquitously expressed in mature tissues and cells in mammals and is involved in various cellular processes, including maintaining cellular homeostasis and protecting against pathological cell and tissue damage .

CREG1 is known to inhibit cell proliferation and enhance differentiation. It interacts with several transcriptional regulators of cell proliferation, such as the coactivators p300 and CBP, which are important in cardiac hypertrophy and heart failure . CREG1 has also been implicated in modulating homeostasis of vascular wall cells and inhibiting inflammation in vascular tissue cells and macrophages .

Studies have demonstrated that CREG1 can attenuate cardiac hypertrophy and fibrosis. Overexpression of CREG1 in the murine heart has been shown to protect against cardiac hypertrophy and fibrosis in vivo . This protective effect is achieved through the regulation of lysosome formation and maturation by modulating the small GTPase protein Rab7, which mediates autophagy in vascular tissue cells .

Given its role in regulating cellular proliferation, differentiation, and inflammation, CREG1 is considered a potential therapeutic target for various cardiovascular diseases, including atherosclerosis and heart failure . Its ability to sustain cellular homeostasis and withstand pathological damage makes it an attractive candidate for therapeutic intervention.