CNN1 Human
Description
CNN1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The CNN1 gene is located on chromosome 19 (19p13.2-p13.1) and contains 7 exons . The human calponin 1 protein consists of 297 amino acids, with a molecular weight of approximately 33.2 kDa and an isoelectric point of 9.1 . This protein is also referred to as basic calponin due to its isoelectric point .
Calponin 1 is a thin filament-associated protein that binds to actin, calmodulin, troponin C, and tropomyosin . Its primary function is to inhibit the actomyosin Mg-ATPase activity, which is essential for muscle contraction . By binding to actin, calponin 1 modulates the interaction between actin and myosin, thereby regulating smooth muscle contraction .
The expression of CNN1 is specific to differentiated mature smooth muscle cells . It is up-regulated in smooth muscle tissues during postnatal development, with a higher content in phasic smooth muscle of the digestive tract . This suggests that calponin 1 plays a significant role in the contractile functions of smooth muscle cells .
Given its role in smooth muscle contraction, calponin 1 is implicated in various physiological and pathological processes. Understanding its function and regulation can provide insights into smooth muscle-related disorders and potential therapeutic targets.
Recombinant human calponin 1 is produced through recombinant DNA technology, allowing for the study of its structure, function, and interactions in a controlled environment. This recombinant protein is valuable for research in muscle physiology and related fields.
