CLMP Human

CXADR-Like Membrane Protein Human Recombinant
Cat. No.
BT270
Source
Escherichia Coli.
Synonyms
CXADR-Like Membrane Protein, CLMP, Adipocyte Adhesion Molecule, Coxsackie- And Adenovirus Receptor-Like Membrane Protein, ACAM, ASAM, Adipocyte-Specific Adhesion Molecule, CAR-Like Membrane Protein, CSBS, CSBM.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

CLMP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (19-235) and having a molecular mass of 26.1 kDa.
CLMP is fused to a 16 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
The CTX protein family, which includes ASAM, consists of type I transmembrane proteins found within the Ig superfamily. These proteins are located in junctional complexes between endothelial and epithelial cells and are believed to be involved in cell-to-cell adhesion. CLMP, a member of this family, plays a role in adipocyte differentiation and the development of obesity. It is also essential for the normal development of the small intestine.
Description
Recombinant human CLMP, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 233 amino acids (residues 19-235). It has a molecular weight of 26.1 kDa. The protein includes a 16 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
The CLMP solution is supplied at a concentration of 0.5 mg/ml and contains 20 mM Tris-HCl buffer (pH 8.0), 0.4 M urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep refrigerated at 4°C. For longer periods, freeze the solution at -20°C. To ensure stability during long-term storage, it is advisable to add a carrier protein such as 0.1% HSA or BSA. Repeated freezing and thawing of the solution should be avoided.
Purity
The purity of the protein is greater than 90.0%, as determined by SDS-PAGE analysis.
Synonyms
CXADR-Like Membrane Protein, CLMP, Adipocyte Adhesion Molecule, Coxsackie- And Adenovirus Receptor-Like Membrane Protein, ACAM, ASAM, Adipocyte-Specific Adhesion Molecule, CAR-Like Membrane Protein, CSBS, CSBM.
Source
Escherichia Coli.
Amino Acid Sequence
MASMTGGQQM GRGSHMTHTE IKRVAEEKVT LPCHHQLGLP EKDTLDIEWL LTDNEGNQKV VITYSSRHVY NNLTEEQKGR VAFASNFLAG DASLQIEPLK PSDEGRYTCK VKNSGRYVWS HVILKVLVRP SKPKCELEGE LTEGSDLTLQ CESSSGTEPI VYYWQRIREK EGEDERLPPK SRIDYNHPGR VLLQNLTMSY SGLYQCTAGN EAGKESCVVR VTVQYVQSIG MVA.

Product Science Overview

Introduction

CXADR (Coxsackievirus and Adenovirus Receptor), also known as CAR, is a type I transmembrane glycoprotein that belongs to the CTX family of the immunoglobulin superfamily . It plays a crucial role in cell adhesion and is involved in various physiological and pathological processes.

Gene and Protein Structure

The CXADR gene encodes a protein that is a receptor for group B coxsackieviruses and subgroup C adenoviruses . The protein is composed of several isoforms due to alternative splicing, which allows it to perform diverse functions in different tissues . The primary structure of CXADR includes an extracellular domain, a single transmembrane region, and a cytoplasmic tail .

Biological Functions

CXADR is a component of the epithelial apical junction complex and functions as a homophilic cell adhesion molecule . It is essential for the integrity of tight junctions and is involved in the transepithelial migration of leukocytes . CXADR interacts with JAML, a transmembrane protein on leukocytes, to mediate the activation of gamma-delta T-cells, which are crucial for tissue homeostasis and repair .

Role in Viral Infections

CXADR acts as a receptor for adenovirus type C and Coxsackievirus B1 to B6 . This interaction facilitates the entry of these viruses into host cells, making CXADR a critical factor in the pathogenesis of viral infections . The receptor’s role in viral entry has made it a target for therapeutic interventions aimed at preventing or treating infections caused by these viruses.

Recombinant CXADR

Recombinant human CXADR is produced using various expression systems to study its structure, function, and interactions . This recombinant protein is used in research to understand its role in cell adhesion, viral entry, and immune response. It is also utilized in the development of antiviral therapies and gene transfer techniques .

Clinical Implications

Mutations or dysregulation of CXADR have been associated with several diseases, including pharyngoconjunctival fever and shipyard eye . Understanding the molecular mechanisms underlying these associations can lead to the development of targeted therapies for these conditions.

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