CLEC2B Human
C-type Lectin Domain Family 2, Member B Human Recombinant
Cat. No.
BT22257
Source
Escherichia Coli.
Synonyms
C-type lectin domain family 2 member B, Activation-induced C-type lectin, C-type lectin superfamily member 2, IFN-alpha-2b-inducing-related protein 1, CLEC2B, AICL, CLECSF2, IFNRG1, HP10085.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
CLEC2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 147 amino acids (26-149 a.a) and having a molecular mass of 16.9kDa.
CLEC2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CLEC2B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
C-type Lectin Domain Family 2, Member B (CLEC2B) is a protein that belongs to the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. This family of proteins is known for its diverse functions, including cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The CLEC2B gene is located on chromosome 12p13 in the natural killer gene complex region, in close proximity to other CTL/CTLD superfamily members. CLEC2B is primarily expressed in lymphoid tissues and most hematopoietic cell types.
Description
Recombinant human CLEC2B protein was produced in E. coli and purified to a single, non-glycosylated polypeptide chain. This protein consists of 147 amino acids (residues 26-149) and has a molecular weight of 16.9 kDa. For purification and detection purposes, a 23 amino acid His-tag is fused to the N-terminus.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
The CLEC2B protein solution is provided at a concentration of 1 mg/ml. The solution also contains 20mM Tris-HCl buffer (pH 8.0), 2M urea, and 10% glycerol.
Stability
For short-term storage (up to 4 weeks), the protein solution can be stored at 4°C. For extended storage, it is recommended to freeze the solution at -20°C. Adding a carrier protein such as HSA or BSA (0.1%) is recommended for long-term storage. Repeated freezing and thawing of the protein solution should be avoided.
Purity
The purity of the CLEC2B protein is greater than 85%, as determined by SDS-PAGE analysis.
Synonyms
C-type lectin domain family 2 member B, Activation-induced C-type lectin, C-type lectin superfamily member 2, IFN-alpha-2b-inducing-related protein 1, CLEC2B, AICL, CLECSF2, IFNRG1, HP10085.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSKLTRDSQ SLCPYDWIGF QNKCYYFSKE EGDWNSSKYN CSTQHADLTI IDNIEEMNFL RRYKCSSDHW IGLKMAKNRT GQWVDGATFT KSFGMRGSEG CAYLSDDGAA TARCYTERKW ICRKRIH.
Product Science Overview
Introduction
Gene and Protein Structure
Functions
Members of the CTL/CTLD superfamily, including CLEC2B, have various roles in biological processes such as:
- Cell adhesion: Facilitating the binding of cells to each other or to the extracellular matrix.
- Cell-cell signaling: Mediating communication between cells.
- Glycoprotein turnover: Involved in the degradation and recycling of glycoproteins.
- Inflammation and immune response: Playing roles in the body’s defense mechanisms .
Expression and Regulation
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