CINP Antibody
Description
Product Specs
Product Science Overview
Cyclin-Dependent Kinase 2 (CDK2) is a crucial enzyme involved in the regulation of the cell cycle. It is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases and plays a significant role in the transition from the G1 phase to the S phase of the cell cycle. CDK2 interacts with various regulatory proteins, including cyclins E and A, to control cell cycle progression .
Cyclin-Dependent Kinase 2 Interacting Protein (CINP) is a protein that interacts with CDK2 and is involved in the regulation of the cell cycle. CINP is known to play a role in the DNA damage response and the maintenance of genomic stability. It is a highly conserved protein and is expressed in various tissues and cell types .
The Mouse Anti Human CINP antibody is a monoclonal antibody derived from the hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CINP amino acids 1-212 purified from E. coli . This antibody is used in various research applications to study the function and regulation of CINP in human cells.
CINP is involved in the regulation of the cell cycle by interacting with CDK2. It has been shown to regulate the phosphorylation of several transcription factors, including Myb-related protein B (B-MYB), Myc proto-oncogene (MYC), and forkhead box proteins O1 (FOXO1) and M1 (FOXM1) . These transcription factors work together to drive the cell cycle through different transition phases.
CINP plays a crucial role in the DNA damage response by maintaining genomic stability. It is involved in the repair of DNA double-strand breaks and the activation of cell cycle checkpoints. This ensures that cells do not progress through the cell cycle with damaged DNA, thereby preventing the accumulation of mutations and maintaining genomic integrity .
The Mouse Anti Human CINP antibody is widely used in research to study the function and regulation of CINP in human cells. It is used in various assays, including Western blotting, immunoprecipitation, and immunofluorescence, to detect and quantify CINP expression and to study its interactions with other proteins .
