CHGB Human
Description
Product Specs
Product Science Overview
Chromogranin B (CHGB) is a member of the granin family of proteins, which are acidic secretory proteins found in the secretory granules of neuroendocrine cells. These proteins play a crucial role in the regulated secretion of hormones and neurotransmitters. Human recombinant Chromogranin B is a synthetically produced version of this protein, used extensively in research to understand its functions and potential therapeutic applications.
The discovery of chromogranins dates back to the mid-20th century. In 1953, chromaffin granules were identified as co-storage sites for catecholamines and ATP . This discovery was soon followed by the identification of uniquely acidic proteins within these granules, leading to the classification of chromogranins. Chromogranin A (CgA) was the first to be identified, followed by Chromogranin B (CgB) and Secretogranin II (SgII) .
Chromogranin B is characterized by its acidic nature and the presence of numerous pairs of basic amino acids . It exists in both soluble and membrane-bound forms, making it dimorphic . This protein is critical for the formation of anion channels on the cell surface during regulated secretion . These channels are essential for maintaining ion homeostasis within secretory granules, which is necessary for the proper storage and release of hormones and neurotransmitters .
Chromogranin B plays a vital role in the neuroendocrine system. It is involved in the regulated secretion of hormones and neurotransmitters, which are crucial for various physiological processes. The protein’s ability to form anion channels helps maintain the ion balance within secretory granules, ensuring the proper functioning of neuroendocrine cells .
Human recombinant Chromogranin B is widely used in research to study its structure, function, and potential therapeutic applications. Recent studies have shown that Chromogranin B is critical for the appearance of robust anion conductances on the surface of neuroendocrine cells after regulated secretion . This makes it a potential target for therapeutic interventions in neurodegenerative diseases and other conditions related to ion homeostasis .
