CENPM Human

CENPM is structurally related to GTPases but does not bind guanosine triphosphate (GTP). It interacts with other proteins in the CCAN, such as CENP-I, to ensure the correct assembly of the kinetochore and proper chromosome alignment . The protein is involved in the recruitment of the CENPA-CAD (nucleosome distal) complex, which is crucial for the incorporation of newly synthesized CENPA into centromeres .

During cell division, the centromere is responsible for the accurate segregation of chromosomes to daughter cells. CENPM, as part of the CCAN, helps maintain centromere identity and ensures the stability of the kinetochore-microtubule attachments . This is vital for the transmission of an intact genome to daughter cells, which is a fundamental requirement for cellular and organismal viability .

Mutations or dysregulation of CENPM can lead to defects in kinetochore assembly and chromosome alignment, resulting in genomic instability. This has been associated with various diseases, including certain types of cancer . For instance, upregulation of CENPM has been linked to breast carcinogenesis, highlighting its potential role in cancer progression and immune infiltration .

Human recombinant CENPM is used in various research applications to study its function and role in cell division. By understanding the molecular mechanisms involving CENPM, researchers aim to develop therapeutic strategies for diseases associated with centromere and kinetochore dysfunctions.