CDHR5 Mouse
Sf9, Baculovirus cells.
Cadherin-related family member 5, Mu-protocadherin, Cdhr5, Mucdhl, Mupcdh, 1810074H01Rik, AI481143
Greater than 90.0% as determined by SDS-PAGE.
Description
CDHR5 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 621 amino acids (29-641 a.a) and having a molecular mass of 66.3kDa.
CDHR5 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Cadherin-related family member 5, Mu-protocadherin, Cdhr5, Mucdhl, Mupcdh, 1810074H01Rik, AI481143
Sf9, Baculovirus cells.
QTQVCSVNQT IFRVEENTTV SEPLVNIFVP DGLHVTLGPL STPYAFRIEG KDLFLNVTPD YEENSLLQAD VECKRGDAVV VRLEVFVAVL DINDNAPKFS FEIKTFNVSE DTKVNTTVIP ETQLKATDAD INDILVYTLQ EVTPNASKFF SLEGVNYPAL KLDQTLDYFK NQNMTFMLLA RDTWEENVEP SHTATATLVL NTLPADLRTP WFLPCSFTDG YVCIHAQYSA VVPTGHKLPS PLIMSPGPIY AVDGDQAINQ SIIYSIIAGN TDGTFIINAH DGNLTMTKSI PSPMKFTLLI RADQEDMAQY SVTQAIVEAR SVTGNPLQFS QSLYYGTVVL GSEAGTAVKD KTFPSEILRI QAQYPGFPDL NSAVTYRVTN SSEFMMNKDI MLTAVPMEEA RTIRVEVEAS NTVTKDTATA VVEIQVSERE LPSTEFPTPP EAGGTTGPSS NTTMEAPLTS GTSQRPATTS SGGSVGPFPP GGTTLRPPTP ASSIPGGSPT LGTSTSPQTT TPGGDSAQTP KPGTSHPTAP TSRTSTSLMT TSSRSDSTQT PKPGTSQPMV PIPGASTSSQ PATPSGSSPQ TPKPGTSQST ATGPISGAGE QGDGQRFSTV DMALEHHHHH H
Product Science Overview
- Gene Location: The Cdhr5 gene is located on chromosome 7 in mice, specifically at the position 140848996-140856699 bp on the negative strand .
- Protein Structure: CDHR5 is a protein-coding gene that encodes a mucin-like protein with nonpolymorphic tandem repeats rich in proline, serine, and threonine, similar to mucin proteins. It also contains calcium-binding motifs characteristic of cadherins .
- Cell Adhesion: CDHR5 plays a crucial role in cell-cell adhesion, particularly in epithelial cells. It forms calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli, which helps in the packing of microvilli at the apical membrane of epithelial cells .
- Microvilli and Brush Border Differentiation: Through its cytoplasmic domain, CDHR5 interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex (IMAC). This complex is central to the differentiation of microvilli and the epithelial brush border .
- Orthologs and Paralogs: CDHR5 has human orthologs and is related to other cadherin family members. An important paralog of this gene is DCHS2 .
- Phenotypes: Mice homozygous for a knock-out allele of Cdhr5 exhibit a slight increase in cell proliferation in the intestinal epithelium but no significant alterations in lifespan or spontaneous tumor incidence .
- Associated Diseases: In humans, mutations in the CDHR5 gene have been associated with conditions such as Usher Syndrome and Adams-Oliver Syndrome .
- Cancer Research: The region where CDHR5 is located is involved in loss of heterozygosity events in breast and prostate cancer, making it a potential area of interest for cancer research .
