CD8B Human

CD8B is a member of the immunoglobulin superfamily and contains one Ig-like V-type (immunoglobulin-like) domain . The CD8 molecule can exist as either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain . Both alpha and beta chains share significant homology to immunoglobulin variable light chains .

The CD8 molecule acts as a co-receptor for the T-cell receptor (TCR) and is involved in the activation of T cells. It interacts with MHC class I molecules on APCs, facilitating the recognition of antigens by the TCR . This interaction is crucial for the immune response against intracellular pathogens, such as viruses, and for the elimination of cancerous cells .

Recombinant CD8B refers to the CD8 beta protein that has been produced using recombinant DNA technology. This involves inserting the gene encoding CD8B into an expression system, such as bacteria or mammalian cells, to produce the protein in large quantities . Recombinant CD8B is often used in research to study the function of the CD8 molecule and its role in the immune response .

Recombinant CD8B has several applications in biomedical research and clinical diagnostics. It is used in flow cytometry to identify and isolate CD8+ T cells from blood samples . It is also used in functional assays to study T cell activation and cytotoxicity . Additionally, recombinant CD8B can be used to generate antibodies against the CD8 molecule, which are valuable tools for immunological research .

The CD8 molecule, including its beta subunit, is of significant clinical interest due to its role in immune responses. Alterations in CD8 expression or function can lead to immune deficiencies or contribute to the pathogenesis of various diseases . For example, CD8+ T cells are critical in controlling viral infections and tumor surveillance. Therefore, understanding the biology of CD8B and its interactions is essential for developing immunotherapies and vaccines .