CD79B Human, Sf9
CD79b Molecule, CD79B Antigen (Immunoglobulin-Associated Beta), CD79b Molecule, Immunoglobulin-Associated Beta, Immunoglobulin-Associated B29 Protein, B-Cell-Specific Glycoprotein B29, Ig-Beta, IGB, B29, B-Cell Antigen Receptor Complex-Associated Protein Beta Chain, CD79b Antigen, CD79B, AGM6.
Greater than 90.0% as determined by SDS-PAGE.
Description
CD79B Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 140 amino acids (29-159a.a.) and having a molecular mass of 16.3kDa (Molecular size on SDS-PAGE will appear at approximately 18-28 kDa).
CD79B is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
CD79b Molecule, CD79B Antigen (Immunoglobulin-Associated Beta), CD79b Molecule, Immunoglobulin-Associated Beta, Immunoglobulin-Associated B29 Protein, B-Cell-Specific Glycoprotein B29, Ig-Beta, IGB, B29, B-Cell Antigen Receptor Complex-Associated Protein Beta Chain, CD79b Antigen, CD79B, AGM6.
ADPARSEDRY RNPKGSACSR IWQSPRFIAR KRGFTVKMHC YMNSASGNVS WLWKQEMDEN PQQLKLEKGR MEESQNESLA TLTIQGIRFE DNGIYFCQQK CNNTSEVYQG CGTELRVMGF STLAQLKQRN TLKDHHHHHH.
Product Science Overview
CD79B, also known as B29 or Ig-β, is a critical component of the B-cell receptor (BCR) complex. It is a single-spanning transmembrane protein that forms a heterodimer with CD79A (Ig-α). This heterodimer is essential for the surface expression and signaling of the BCR, which plays a pivotal role in B-cell development, activation, and differentiation .
CD79B is predominantly expressed on B lineage cells. The BCR complex, consisting of surface-bound immunoglobulin (Ig) and the CD79A/CD79B heterodimer, initiates crucial signaling pathways upon antigen recognition. These signals are vital for B-cell maturation and immune response . CD79B also supports antigen-independent survival signals, known as tonic signaling, which are necessary for maintaining B-cell homeostasis .
Recombinant CD79B can be produced using the Sf9 insect cell expression system. Sf9 cells, derived from the fall armyworm Spodoptera frugiperda, are commonly used for the production of recombinant proteins due to their high expression levels and ability to perform post-translational modifications. The recombinant CD79B protein produced in Sf9 cells is often used in research to study BCR signaling and to develop therapeutic antibodies targeting B-cell malignancies .
CD79B has gained significant attention in the field of oncology, particularly in the treatment of B-cell lymphomas. It is a target for chimeric antigen receptor (CAR) T-cell therapy, which has shown promising results in treating relapsed or refractory B-cell lymphomas. CD79B is extensively expressed on tumor cells of various B-cell lymphomas, making it an attractive target for immunotherapy . Additionally, CD79B is a target of polatuzumab vedotin, an antibody-drug conjugate that has improved the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) .
