CD62E Antibody
Description
Product Specs
Product Science Overview
E-Selectin, also known as CD62E, is a cell adhesion molecule expressed on endothelial cells activated by cytokines. It plays a crucial role in the inflammatory response by mediating the adhesion of leukocytes to the endothelium . The mouse anti-human E-Selectin antibody is used extensively in research to study the function and expression of E-Selectin in various biological processes.
E-Selectin is a member of the selectin family of cell adhesion molecules, which also includes L-Selectin and P-Selectin. It is composed of an N-terminal lectin domain, an epidermal growth factor (EGF)-like domain, and a series of complement regulatory protein (CRP)-like domains . E-Selectin binds to specific carbohydrate ligands on the surface of leukocytes, facilitating their rolling and adhesion to the endothelial cells during inflammation.
E-Selectin expression is induced by pro-inflammatory cytokines such as TNF-α and IL-1β. It is transiently expressed on the surface of endothelial cells in response to these cytokines, playing a key role in the recruitment of leukocytes to sites of inflammation . The expression of E-Selectin is tightly regulated at the transcriptional level to ensure a rapid and localized inflammatory response.
E-Selectin mediates the initial capture and rolling of leukocytes on the endothelial surface, a critical step in the leukocyte extravasation process. This interaction is essential for the subsequent firm adhesion and transmigration of leukocytes into the inflamed tissue . The binding of E-Selectin to its ligands on leukocytes is a highly specific and regulated process, ensuring that leukocytes are efficiently recruited to sites of inflammation.
The mouse anti-human E-Selectin antibody is widely used in research to study the role of E-Selectin in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and cancer. It is used in techniques such as flow cytometry, immunohistochemistry, and Western blotting to detect and quantify E-Selectin expression . Additionally, this antibody is used to investigate the molecular mechanisms underlying E-Selectin-mediated leukocyte adhesion and migration.
