CD36 Mouse
Description
CD36 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
CD36 is a transmembrane protein composed of short amino-terminal and carboxy-terminal cytoplasmic domains, two transmembrane domains, and a large glycosylated extracellular domain . It is expressed by multiple cell types, including monocytes, macrophages, platelets, endothelial cells, adipocytes, and some epithelial cells . The protein has a molecular weight ranging from 70 to 110 kDa .
CD36 has diverse functions due to its ability to bind a wide range of ligands. Some of its key functions include:
- Lipid Metabolism: CD36 binds lipids and facilitates their transport into cells. In macrophages, it acts as a receptor for oxidized low-density lipoprotein (Ox-LDL) and is responsible for Ox-LDL internalization, contributing to the development of atherosclerosis .
- Immune Response: CD36 participates in the innate immune response by acting as a pattern recognition receptor for lipid components of bacterial cell walls and fungal beta-glucans .
- Angiogenesis: Binding of thrombospondin-1 (TSP-1) to CD36 inhibits angiogenesis .
- Cellular Adhesion: CD36 interacts with other cell surface receptors, including TLRs, integrins, and tetraspanins, influencing cellular signaling and adhesion .
Recombinant CD36 proteins are produced using various expression systems, including insect cells . These recombinant proteins are used in research to study the protein’s structure, function, and interactions. They are typically purified to high levels of purity (>95%) and are suitable for applications such as SDS-PAGE .
CD36 is widely studied in the context of cardiovascular diseases, metabolic disorders, and immune responses. Its role in lipid metabolism and atherosclerosis makes it a target for therapeutic interventions. Additionally, its involvement in immune responses and angiogenesis has implications for cancer research and infectious diseases.
