CD300E Human

The CD300E protein is encoded by the CD300E gene (also known as CD300LE, CLM2, IREM2) . The recombinant human CD300E protein is typically expressed in HEK293 cells and consists of 394 amino acids, predicting a molecular mass of approximately 44.3 kDa . The protein is often produced with an Fc tag, which facilitates its purification and detection .

CD300E acts as an activating receptor on myeloid cells. It interacts with the TYRO protein tyrosine kinase-binding protein, which is involved in signal transduction pathways that activate immune responses . The activation of CD300E can lead to various immune functions, including the production of cytokines and the enhancement of phagocytosis .

The CD300 family, including CD300E, is emerging as an important group of regulators in the immune system. These proteins are involved in various immune responses and have potential clinical relevance in the context of immune-related diseases . Understanding the role of CD300E and other CD300 molecules can provide insights into the development of new therapeutic strategies for treating immune disorders.

Recombinant human CD300E protein is produced using DNA sequences encoding the protein, which are expressed in host cells such as HEK293 cells . The protein is then purified and formulated for various research and clinical applications. The recombinant protein is typically lyophilized and can be reconstituted for use in experiments .

Recombinant CD300E protein is stable for up to twelve months when stored at -20°C to -80°C under sterile conditions . It is recommended to aliquot the protein to avoid repeated freeze-thaw cycles, which can affect its stability and activity .