CD164L2 Human
Description
Product Specs
Product Science Overview
CD164L2 is a member of the CD164 family, which includes sialomucin-like molecules. These molecules are characterized by their mucin-like domains, which play crucial roles in cell adhesion and signaling. CD164L2 is expressed in various tissues and has been associated with several biological functions and disease states .
The human recombinant form of CD164L2 is typically produced using recombinant DNA technology. This involves cloning the CD164L2 gene into an expression vector, which is then introduced into a host cell, such as E. coli. The host cells express the CD164L2 protein, which is subsequently purified through various chromatographic techniques to obtain the recombinant protein .
CD164L2 is predicted to be an integral component of the membrane and is active in cytoplasmic vesicles. It is involved in cell adhesion and signaling processes, which are critical for various cellular functions. The protein has a molecular mass of approximately 14.4 kDa and consists of 135 amino acids .
CD164L2 plays a role in hematopoiesis by facilitating the adhesion of hematopoietic progenitor cells to the bone marrow stroma. This interaction is crucial for the regulation of hematopoietic progenitor cell growth and differentiation. Additionally, CD164L2 has been implicated in the regulation of immune responses and may have roles in other physiological processes .
The expression and function of CD164L2 are regulated by various factors, including transcription factors and signaling pathways. Promoters and enhancers associated with the CD164L2 gene play a significant role in its transcriptional regulation. These regulatory elements ensure the precise expression of CD164L2 in specific tissues and under certain physiological conditions .
CD164L2 has been associated with several diseases, including Hypertrichosis Universalis Congenita, Ambras Type, and Hypogonadotropic Hypogonadism 12 With or Without Anosmia. Understanding the role of CD164L2 in these conditions can provide insights into potential therapeutic targets and strategies for treatment .
