CD163 Porcine
Description
The CD163 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
In pigs, CD163 is particularly significant due to its role as a receptor for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). PRRSV is a highly contagious virus that has caused substantial economic losses in the swine industry globally. The virus targets cells of the monocyte-macrophage lineage, utilizing porcine CD163 (pCD163) as an indispensable cellular receptor for infection .
Recombinant CD163 proteins have been developed to study and combat PRRSV. These recombinant proteins are engineered versions of the natural CD163 receptor, designed to retain the functional properties necessary for PRRSV binding and entry. By expressing recombinant CD163 in various cell lines, researchers can better understand the virus’s mechanisms of infection and develop targeted antiviral strategies .
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Cell Line Development: Researchers have successfully transfected the gene encoding pCD163 into non-permissive cell lines, making them susceptible to PRRSV infection. This has facilitated the study of PRRSV pathogenesis and the host immune response .
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Antiviral Strategies: Novel antiviral compounds, such as nanobody peptide conjugates (NPCs), have been developed using CD163-derived peptides. These NPCs demonstrate broad inhibitory effects against various PRRSV strains by interfering with the virus’s ability to bind to CD163 .
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Genetic Engineering: Advances in gene editing have enabled the creation of CD163 knockout pigs, which are resistant to PRRSV infection. This approach holds promise for developing PRRSV-resistant pig breeds, potentially reducing the impact of the virus on the swine industry .
