CBX5 Human
Description
CBX5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The CBX5 gene is located on chromosome 12 (12q13.13) in humans . The gene encodes a protein that is 191 amino acids in length and contains six exons . The protein has two main domains:
- N-terminal Chromodomain (CD): This domain binds to histone proteins via methylated lysine residues, specifically recognizing histone H3 tails methylated at lysine 9 (H3K9me) .
- C-terminal Chromoshadow Domain (CSD): This domain is responsible for homodimerization and interaction with various chromatin-associated non-histone proteins .
CBX5 is enriched in heterochromatin and is associated with centromeres . It plays a significant role in the formation of functional kinetochores through its interaction with essential kinetochore proteins . The protein is involved in several key biological processes:
- Epigenetic Repression: By binding to methylated histone H3, CBX5 contributes to the repression of gene expression .
- Chromatin Organization: CBX5 helps in maintaining the structure of heterochromatin, ensuring proper chromosome segregation during cell division .
- DNA Damage Response: CBX5 is involved in the cellular response to DNA damage, aiding in the repair process .
Mutations or dysregulation of the CBX5 gene have been associated with various diseases, including Fanconi Anemia and Reynolds Syndrome . The protein’s role in maintaining chromatin structure and gene expression makes it a potential target for therapeutic interventions in diseases related to chromatin dysfunction.
Recombinant CBX5 (Human) is produced using recombinant DNA technology, which allows for the expression of the human CBX5 gene in a host organism, such as bacteria or yeast. This recombinant protein is used in research to study the function and interactions of CBX5 in various biological processes.
