CBR1 PAT2D6AT Antibody

Carbonyl Reductase-1 PAT2D6AT, Mouse Anti Human
Cat. No.
BT14551
Source
Synonyms
CBR, hCBR1, SDR21C1, CBR1, Carbonyl reductase [NADPH] 1, NADPH-dependent carbonyl reductase 1, Prostaglandin-E(2) 9-reductase, Prostaglandin 9-ketoreductase, 15-hydroxyprostaglandin dehydrogenase [NADP+], CRN.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
CBR1, a ubiquitous monomeric NADPH-dependent oxidoreductase, exhibits broad substrate specificity for carbonyl compounds. Found extensively in human tissues, CBR1 participates in the metabolism of toxic environmental quinones and pharmacologically significant substrates such as the anticancer drug doxorubicin. Furthermore, CBR1 catalyzes the conversion of prostaglandin E2 to prostaglandin F2-alpha.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The antibody solution has a concentration of 1mg/ml and is formulated in a buffer consisting of PBS at pH 7.4, 10% glycerol, and 0.02% sodium azide.
Storage Procedures
For short-term storage of up to one month, maintain the antibody at 4°C. For extended storage, keep at -20°C. Repeated freeze-thaw cycles should be avoided.
Stability / Shelf Life
The antibody remains stable for 12 months when stored at -20°C and for 1 month at 4°C.
Applications
The CBR1 antibody has undergone rigorous testing in various applications, including ELISA, Western blot analysis, immunocytochemistry/immunofluorescence (ICC/IF), and flow cytometry, to confirm its specificity and reactivity. However, it is essential to optimize the antibody concentration for each specific application to achieve optimal results.
Synonyms
CBR, hCBR1, SDR21C1, CBR1, Carbonyl reductase [NADPH] 1, NADPH-dependent carbonyl reductase 1, Prostaglandin-E(2) 9-reductase, Prostaglandin 9-ketoreductase, 15-hydroxyprostaglandin dehydrogenase [NADP+], CRN.
Purification Method
CBR1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT2D6AT.
Immunogen
Anti-human CBR1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CBR1 amino acids 1-277 purified from E. coli.
Ig Subclass
Mouse IgG2a heavy chain and k light chain.

Product Science Overview

Structure and Function

CBR1 is a cytoplasmic enzyme that plays a significant role in the detoxification of reactive carbonyl compounds. It has a broad substrate specificity and is known to reduce a variety of carbonyl-containing compounds to their corresponding alcohols . The enzyme’s activity is essential for the metabolism of several therapeutic drugs and the detoxification of harmful substances.

Monoclonal Antibody PAT2D6AT

The PAT2D6AT clone is a monoclonal antibody developed in mice that specifically targets human CBR1 . Monoclonal antibodies are produced by identical immune cells that are clones of a unique parent cell, ensuring specificity and uniformity in their action. The PAT2D6AT clone is particularly useful in various scientific applications, including:

  • Western Blotting (WB)
  • Immunohistochemistry (IHC)
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunocytochemistry/Immunofluorescence (ICC/IF)

These applications are crucial for detecting and quantifying CBR1 in different biological samples, aiding in research related to cell biology, metabolism, and signal transduction.

Applications and Importance

CBR1 antibodies, including the PAT2D6AT clone, are valuable tools in biomedical research. They help in studying the expression and function of CBR1 in various tissues and under different physiological and pathological conditions. Understanding CBR1’s role can provide insights into its involvement in drug metabolism, resistance mechanisms, and its potential as a therapeutic target.

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THE BIOTEK
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