CBR1 Antibody
Description
Product Specs
Product Science Overview
Monoclonal antibodies (mAbs) are antibodies that are made by identical immune cells, all clones of a unique parent cell. They have monovalent affinity, binding to the same epitope. Monoclonal mouse anti-human antibodies are produced by immunizing mice with human antigens, leading to the production of antibodies that specifically target human proteins .
Development and Applications
The development of monoclonal antibodies involves several steps, including the immunization of mice, fusion of spleen cells with myeloma cells to create hybridomas, and screening for the desired antibody specificity . These antibodies are used in various applications, including diagnostics, therapeutics, and research. They are particularly valuable in immunohistochemistry (IHC) for detecting specific proteins in tissue samples .
Humanization of Mouse Antibodies
One of the challenges with using mouse monoclonal antibodies in humans is the potential for an immune response against the mouse-derived components. To address this, techniques such as CDR-grafting and resurfacing are used to humanize these antibodies, reducing their immunogenicity while retaining their specificity .
