CAPG Antibody
Description
Product Specs
Product Science Overview
Capping Protein Gelsolin-Like, also known as CapG, is a member of the gelsolin family of actin-modulating proteins. These proteins play a crucial role in various cellular processes, including cell signaling, receptor-mediated membrane ruffling, phagocytosis, and motility. CapG is particularly interesting due to its involvement in the regulation of actin filament dynamics, which is essential for cell movement and stability .
CapG has garnered significant attention for its role in oncogenesis, particularly in the context of cancer cell migration and invasion. Studies have shown that CapG is frequently upregulated in various types of cancer, including oral squamous cell carcinoma (OSCC) and non-small cell lung cancer (NSCLC). The overexpression of CapG in these cancers is associated with advanced disease stages and poor prognosis .
CapG functions by binding to the barbed ends of actin filaments, thereby preventing the addition or loss of actin monomers. This capping activity is crucial for maintaining the stability and organization of the actin cytoskeleton. The regulation of actin dynamics by CapG is essential for various cellular processes, including cell shape maintenance, motility, and division .
The expression levels of CapG have been studied extensively in the context of cancer. In OSCC, CapG expression is significantly higher in tumor tissues compared to normal tissues. This upregulation is correlated with the TNM stage grading of the cancer, suggesting that CapG could serve as a potential biomarker for cancer progression and prognosis . Similarly, in NSCLC, high levels of CapG expression are associated with increased tumor motility and multidrug resistance, further highlighting its potential as a therapeutic target .
The development of mouse anti-human CapG antibodies has facilitated the study of CapG expression in various tissues. These antibodies are used in immunohistochemistry (IHC) and real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) to detect and quantify CapG expression at the protein and mRNA levels, respectively. These techniques have been instrumental in elucidating the role of CapG in cancer and other diseases .
