CAMK2N1 Human
Description
CAMK2N1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Calcium/Calmodulin Dependent Protein Kinase II (CaMKII) is a multifunctional enzyme that plays a crucial role in various cellular processes, particularly in the central nervous system and cardiac tissues. The regulation of CaMKII activity is essential for maintaining cellular homeostasis and function. One of the key regulatory mechanisms involves the inhibition of CaMKII by specific inhibitors, such as Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 (CaMKII Inhibitor 1).
CaMKII is a serine/threonine-specific protein kinase that is activated by the binding of calcium/calmodulin complexes. It is composed of multiple subunits, forming a holoenzyme with a unique dodecameric structure. This enzyme is involved in various signaling pathways, including those regulating synaptic plasticity, memory formation, and cardiac muscle contraction.
CaMKII Inhibitor 1 is a protein that specifically inhibits the activity of CaMKII. It binds to the kinase domain of CaMKII, preventing its activation and subsequent phosphorylation of target proteins. This inhibition is crucial for modulating the activity of CaMKII in response to changes in intracellular calcium levels.
Human recombinant CaMKII Inhibitor 1 is a laboratory-produced version of the natural inhibitor protein. It is generated using recombinant DNA technology, which involves inserting the gene encoding CaMKII Inhibitor 1 into a suitable expression system, such as bacteria or insect cells. This allows for the production of large quantities of the protein for research and therapeutic purposes.
The availability of human recombinant CaMKII Inhibitor 1 has significantly advanced our understanding of CaMKII regulation and its role in various diseases. For instance, studies have shown that CaMKII activity is dysregulated in conditions such as heart failure, diabetes, and neurodegenerative diseases . By using CaMKII Inhibitor 1, researchers can investigate the specific contributions of CaMKII to these pathologies and develop potential therapeutic strategies.
The therapeutic potential of CaMKII Inhibitor 1 is being explored in various clinical settings. For example, in cardiac diseases, inhibition of CaMKII has been shown to improve cardiac function and reduce arrhythmias . Similarly, in neurodegenerative diseases, targeting CaMKII may help in mitigating synaptic dysfunction and neuronal loss.
